ReviewBMC nephrology2019
IgG4-related kidney disease (IgG4-RKD) with membranous nephropathy as its initial manifestation: report of one case and literature review.
Review in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Concurrent IgG4-related membranous nephropathy and proliferative diabetic kidney disease: a diagnostic dilemma and therapeutic strategy in long-standing diabetes.BMC nephrology · 2025Article
- C3 Glomerulonephritis Associated With Unusual IgG4 Antifactor H in IgG4-related Disease.Kidney medicine · 2025Article
- A case of PLA2R-positive membranous nephropathy with subsequent development of IgG4-related disease.CEN case reports · 2025Article
- A rare case: IgG4-related chronic inflammatory disease with kidney involvement.Clinical case reports · 2024Article
- Progression to End-Stage Renal Disease Due to IgG4-Related Nephritis Refractory to Rituximab.Cureus · 2023Article
- A Case of M-Type Phospholipase A2 Receptor-Associated Membranous Nephropathy With IgG4-Positive Cells Infiltration in the Interstitium.Clinical medicine insights. Case reports · 2022Article
- IgG4-related nephritis and interstitial pulmonary disease complicated by invasive pulmonary fungal infection: a case report.BMC nephrology · 2021Article
- Immune Dysregulation in IgGFrontiers in immunology · 2021Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIgG4-related disease (IgG4-RD) often affects multiple organs and tissues, especially the kidneys, and is characterized by interstitial nephritis, obstructive nephropathy, and in rare cases glomerulopathy (including membranous nephropathy). CASE PRESENTATION: In this article, we report a patient with nephrotic syndrome as the only initial manifestation. Membranous nephropathy was confirmed by renal biopsy, but without any renal interstitial lesions. The nephrotic syndrome completely resolved after treatment with immunosuppressants but recurred after drug withdrawal, which was accompanied by acute kidney injury. Ultimately, IgG4-related interstitial nephritis with membranous nephropathy was confirmed by a second renal biopsy. After routine administration of steroids and cyclophosphamide, renal function returned to normal after 2 months, and nephrotic syndrome was ameliorated after 5 months.
conclusionSpecial attention should be paid to this rare condition in the clinical setting. In patients with membranous nephropathy (MN) that is accompanied by multi-system damage, impaired renal function, elevated IgG4 levels (absolute or relative value), negative PLA2R, and/or renal interstitial plasma cell infiltration, the possibility of IgG4-related kidney disease (IgG4-RKD) should be carefully assessed.
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