Evidence map›Paper›PMID 31311495›Full record

ArticleBMC infectious diseases2019

Interaction of nutritional status and diabetes on active and latent tuberculosis: a cross-sectional analysis.

Rachel W Kubiak, Sonali Sarkar, C Robert Horsburgh, Gautam Roy, Mario Kratz, Ayiraveetil Reshma, Selby Knudsen, Padmini Salgame, Jerrold J Ellner, Paul K Drain and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 6 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Rachel W KubiakDepartment of Epidemiology, University of Washington, 1959 NE Pacific Street, Health Sciences Building, Box 357236, Seattle, WA, 98195, USA. rwkubiak@uw.edu.ORCID http://orcid.org/0000-0002-2315-4112
Sonali SarkarDepartment of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
C Robert HorsburghDepartment of Epidemiology, Boston University School of Public Health, Boston, USA.
Gautam RoyDepartment of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Mario KratzDepartment of Epidemiology, University of Washington, 1959 NE Pacific Street, Health Sciences Building, Box 357236, Seattle, WA, 98195, USA.
Ayiraveetil ReshmaDepartment of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Selby KnudsenDepartment of Epidemiology, Boston University School of Public Health, Boston, USA.
Padmini SalgameCenter for Emerging Pathogens, Department of Medicine, Rutgers-New Jersey Medical School, Newark, USA.
Jerrold J EllnerDepartment of Epidemiology, Boston University School of Public Health, Boston, USA.
Paul K DrainDepartment of Epidemiology, University of Washington, 1959 NE Pacific Street, Health Sciences Building, Box 357236, Seattle, WA, 98195, USA.
Natasha S HochbergDepartment of Epidemiology, Boston University School of Public Health, Boston, USA.
Jawaharlal Institute of Post Graduate Medical Education and Research · INUniversity of Washington · USBoston University · USRutgers, The State University of New Jersey · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
CRDF Global USB1-31150-XX-13National Science Foundation OISE-9531011NCATS NIH HHS TL1 TR002318NIDDK NIH HHS P30 DK017047
6 · The paper itself

Abstract

backgroundMalnutrition and diabetes are risk factors for active tuberculosis (TB), possible risk factors for latent TB infection (LTBI), and may interact to alter their effect on these outcomes. Studies to date have not investigated this interaction.

methodsWe enrolled 919 newly diagnosed active TB patients and 1113 household contacts at Primary Health Centres in Puducherry and Tamil Nadu, India from 2014 to 2018. In cross-sectional analyses, we used generalized estimating equations to measure additive and multiplicative interaction of body mass index (BMI) and diabetes on two outcomes, active TB and LTBI.

resultsAmong overweight or obese adults, active TB prevalence was 12-times higher in diabetic compared to non-diabetic participants, 2.5-times higher among normal weight adults, and no different among underweight adults (P for interaction < 0.0001). Diabetes was associated with 50 additional active TB cases per 100 overweight or obese participants, 56 per 100 normal weight participants, and 17 per 100 underweight participants (P for interaction < 0.0001). Across BMI categories, screening 2.3-3.8 active TB patients yielded one hyperglycemic patient. LTBI prevalence did not differ by diabetes and BMI*diabetes interaction was not significant.

conclusionsBMI and diabetes are associated with newly diagnosed active TB, but not LTBI. Diabetes conferred the greatest risk of active TB in overweight and obese adults whereas the burden of active TB associated with diabetes was similar for normal and overweight or obese adults. Hyperglycemia was common among all active TB patients. These findings highlight the importance of bi-directional diabetes-active TB screening in India.

Indexed as

Nutritional StatusAdultBody Mass IndexCross-Sectional StudiesDiabetes MellitusFamily CharacteristicsFemaleHumansHyperglycemiaIndiaLatent TuberculosisMaleMiddle AgedOverweightPrevalenceRisk FactorsBody mass indexCross-sectional analysisDiabetes mellitusIndiaLatent tuberculosisPrevalenceTuberculosisUnderweight

Identifiers

PMID31311495
PMCPMC6636094
OpenAlexW2958995910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.