ArticleBMC genetics2019
Genome-wide association analysis for β-hydroxybutyrate concentration in Milk in Holstein dairy cattle.
Article in BMC genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 63 citations in OpenAlex.
- Assessing the genetic potential of a milk mid-infrared prediction of heat stress response in dairy cows using a temperature-humidity index-independent approach.JDS communications · 2026Article
- Genome-wide association study reveals key genomic regions underlying colostrability in Italian Holstein cattle.Genetics, selection, evolution : GSE · 2026Article
- Genomic investigation of the fat-to-protein ratio: functional analysis of a biomarker associated with ketosis in Iranian Holstein dairy cows.Tropical animal health and production · 2026Article
- Distinct adaptation and ancestral retention signals in African and European indigenous cattle genomes.Communications biology · 2026Article
- Detection of selection signatures in indigenous African cattle reveals genomic footprints of adaptation, production and temperament traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Mapping genes for resilient dairy cows by means of across-breed genome-wide association analysis.BMC genomics · 2025Article
- Innovations in Cattle Breeding Technology: Prospects in the Era of Gene Editing.Animals : an open access journal from MDPI · 2025Review
- Mendelian randomisation to uncover causal associations between conformation, metabolism, and production as potential exposure to reproduction in German Holstein dairy cattle.Genetics, selection, evolution : GSE · 2025Article
- Persistently high concentrations of β-hydroxybutyrate affect hepatic SOD2 expression and blood SOD activity in high-yielding dairy cows.BMC veterinary research · 2025Article
- Exploring the Genetic Basis of Ketosis: Preliminary GWAS Findings on Beta-Hydroxybutyrate Levels in Holstein Cattle.International journal of genomics · 2025Article
- Review
- Genomic prediction of blood biomarkers of metabolic disorders in Holstein cattle using parametric and nonparametric models.Genetics, selection, evolution : GSE · 2024Article
- Integrating on-farm and genomic information improves the predictive ability of milk infrared prediction of blood indicators of metabolic disorders in dairy cows.Genetics, selection, evolution : GSE · 2023Article
- Candidate genes for mastitis resistance in dairy cattle: a data integration approach.Journal of animal science and biotechnology · 2023Article
- Detection of whole genome selection signatures of Pakistani Teddy goat.Molecular biology reports · 2021Article
- Investigation of β-hydroxybutyrate in early lactation of Simmental cows: Genetic parameters and genomic predictions.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2021Article
- Genome-Wide Association Study Identifies Candidate Genes Associated with Feet and Leg Conformation Traits in Chinese Holstein Cattle.Animals : an open access journal from MDPI · 2021Article
- Hyperketonemia Predictions Provide an On-Farm Management Tool with Epidemiological Insights.Animals : an open access journal from MDPI · 2021Article
- Genomic Loci Affecting Milk Production in German Black Pied Cattle (DSN).Frontiers in genetics · 2021Article
- Taurine and Indicine Haplotype Representation in Advanced Generation Individuals From Three American Breeds.Frontiers in genetics · 2021Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKetosis in dairy cattle has been shown to cause a high morbidity in the farm and substantial financial losses to dairy farmers. Ketosis symptoms, however, are difficult to identify, therefore, the amount of ketone bodies (mainly β-hydroxybutyric acid, BHB) is used as an indicator of subclinical ketosis in cows. It has also been shown that milk BHB concentrations have a strong correlation with ketosis in dairy cattle. Mid-infrared spectroscopy (MIR) has recently became a fast, cheap and high-throughput method for analyzing milk components. The aim of this study was to perform a genome-wide association study (GWAS) on the MIR-predicted milk BHB to identify genomic regions, genes and pathways potentially affecting subclinical ketosis in North American Holstein dairy cattle.
resultsSeveral significant regions were identified associated with MIR-predicted milk BHB concentrations (indicator of subclinical ketosis) in the first lactation (SCK1) and second and later lactations (SCK2) in Holstein dairy cows. The strongest association was located on BTA6 for SCK1 and BTA14 on SCK2. Several SNPs on BTA6 were identified in regions and variants reported previously to be associated with susceptibility to ketosis and clinical mastitis in Jersey and Holstein dairy cattle, respectively. One highly significant SNP on BTA14 was found within the DGAT1 gene with known functions on fat metabolism and inflammatory response in dairy cattle. A region on BTA6 and three SNPs on BTA20 were found to overlap between SCK1 and SCK2. However, a novel region on BTA20 (55-63 Mb) for SCK2 was also identified, which was not reported in previous association studies. Enrichment analysis of the list of candidate genes within the identified regions for MIR-predicted milk BHB concentrations yielded molecular functions and biological processes that may be involved in the inflammatory response and lipid metabolism in dairy cattle.
conclusionsThe results of this study confirmed several SNPs and genes identified in previous studies as associated with ketosis susceptibility and immune response, and also found a novel region that can be used for further analysis to identify causal variations and key regulatory genes that affect clinical/ subclinical ketosis.
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