ArticleBMC gastroenterology2019
Low vitamin D level was associated with metabolic syndrome and high leptin level in subjects with nonalcoholic fatty liver disease: a community-based study.
Article in BMC gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Beyond bones, vitamin D as a sunshine hormone in type 2 diabetes mellitus and its complications.iScience · 2026Review
- Intersections of vitamin D deficiency, HIV and chronic liver diseases.HIV medicine · 2026Review
- The interplay between childhood obesity and vitamin D deficiency: mechanisms and implications.Frontiers in pediatrics · 2025Review
- Excessive Pregestational Weight and Maternal Obstetric Complications: The Role of Adipokines.International journal of molecular sciences · 2023Review
- Vitamin D improves hepatic alterations inSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Vitamin D insufficiency is associated with inflammation and deregulation of adipokines in patients with metabolic syndrome.BMC endocrine disorders · 2022Article
- Article
- Lipoprotein(a) is Associated with Cardiovascular Events in Low Risk Males: Results from a Health Checkup Cohort with Long-Term Follow-Up.Acta Cardiologica Sinica · 2022Article
- Insulin Resistance and Vitamin D Deficiency: A Link Beyond the Appearances.Frontiers in cardiovascular medicine · 2022Review
- Association and interaction between vitamin D level and metabolic syndrome for non-alcoholic fatty liver disease.Journal of diabetes and metabolic disorders · 2021Article
- Pretreatment withDrug design, development and therapy · 2020Article
- Association of 25 (OH) Vitamin D and Leptin in Individuals with Insulin Resistance.Indian journal of endocrinology and metabolismArticle
- Article
- Study of Cellular Senescence and Vitamin D Deficiency in Nonalcoholic Fatty Liver Disease and The Potential Protective Effect of Vitamin D Supplementation.Journal of clinical and experimental hepatologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThis study aimed to evaluate the association between serum vitamin D levels and nonalcoholic fatty liver disease (NAFLD) parameters, such as metabolic syndrome (MS), inflammatory cytokines (tumor necrosis factor, high sensitive C-reactive protein) and adipokines (adiponectin, leptin).
methodsFrom August 2013 to August 2016, a community-based study was performed in the north-eastern region of Taiwan. All subjects received a demographic survey, blood testing and abdominal ultrasonography (US). The vitamin D level was evaluated by quartile divide or used the classification of deficiency (< 20 ng/ml), insufficiency (20-30 ng/ml) and sufficiency (> 30 ng/ml).
resultsSubjects were divided into NAFLD group and normal control (subjects number = 564 in each group) following abdominal US study and matching age and gender. The mean age was 57.1 years in NAFLD group and 57.5 in control group. Subjects in NAFLD group had a lower mean vitamin D than those in the control group (28.5 ± 9.5 ng/ml vs. 29.9 ± 10.2 ng/ml, P = 0.018). Subjects with serum vitamin D deficiency or insufficiency had higher odds for MS than those with sufficient vitamin D levels [deficiency vs. sufficiency, adjusted odds ratio (aOR) =1.860 (95% CI = 1.234-2.804), P = 0.003; insufficiency vs. sufficiency, aOR = 1.669 (95% CI = 1.237-2.251), P = 0.001]. Similarly, subjects in the lowest quartile of vitamin D had higher odds for MS than those in the highest quartile of vitamin D (aOR = 2.792, 95% CI = 1.719-4.538, P < 0.001). Vitamin D level was positively correlated with age and male, but negatively correlated with serum leptin level.
conclusionSubjects with low vitamin D level had higher odds for MS, but higher levels of leptin, compared to those with high vitamin D levels.
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