ArticleProceedings. Biological sciences2019
Mosquitoes cloak their legs to resist insecticides.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 125 citations in OpenAlex.
- Exploring and Mitigating Insecticide Resistance in Urban Pests with New Synergists and Insecticides.Insects · 2026Review
- Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci.eLife · 2026Article
- Potential of bacteria isolated from chitin-enriched soil against Euschistus heros (Hemiptera: Pentatomidae).Pest management science · 2026Article
- Lipid Metabolism in Insect Vectors of Diseases.Advances in experimental medicine and biology · 2026Review
- Multi-omics insights into mosquito insecticide resistance for integrated vector management.PeerJ · 2026Review
- Cuticle thickening mediates insecticide penetration resistance in Spodoptera litura.Journal of advanced research · 2025Article
- Pyrethroid resistance in Aedes aegypti: genetic mechanisms worldwide, and recommendations for effective vector control.Parasites & vectors · 2025Review
- Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos reducing their lifespan and malaria burden.Nature communications · 2025Article
- The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake.Parasites & vectors · 2025Article
- [Effects of larval feeding amount on development and deltamethrin resistance inNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- A Leg Cuticle Protein Enhances the Resistance ofInternational journal of molecular sciences · 2025Article
- Panoramic view of diversity and function of cuticular proteins in insects and mosquitoes biology.Frontiers in insect science · 2025Review
- Extra-corporeal detoxification in insects.Heliyon · 2024Article
- Potential of MALDI-TOF MS biotyping to detect deltamethrin resistance in the dengue vector Aedes aegypti.PloS one · 2024Article
- Insecticide resistance in the field populations of the Asian tiger mosquitoFrontiers in physiology · 2024Article
- Evaluation of diffuse reflectance spectroscopy for predicting age, species, and cuticular resistance of Anopheles gambiae s.l under laboratory conditions.Scientific reports · 2023Article
- Cuticular competing endogenous RNAs regulate insecticide penetration and resistance in a major agricultural pest.BMC biology · 2023Article
- ABCH2 transporter mediates deltamethrin uptake and toxicity in the malaria vector Anopheles coluzzii.PLoS pathogens · 2023Article
- Cuticular profiling of insecticide resistant Aedes aegypti.Scientific reports · 2023Article
- Selection for insecticide resistance can promote Plasmodium falciparum infection in Anopheles.PLoS pathogens · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread, is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae; however, the emergence of striking resistant phenotypes suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared with susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.