ArticleProceedings. Biological sciences2019
Convergent evolution of cytochrome P450s underlies independent origins of keto-carotenoid pigmentation in animals.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Review
- Inference of Cytochrome P450 Evolutionary History Using Structural and Physicochemical Metrics.Genome biology and evolution · 2025Article
- Bdh1l Gene Expression Is a Potential Molecular Factor in the Evolution of Carotenoid-Based Colour Diversity of Cichlid Fishes.Molecular ecology · 2025Article
- Molecular basis governing diapause and pigmentation in the hawthorn spider mite, Amphitetranychus viennensis.BMC biology · 2025Article
- Carotenoid-based immune response in sea cucumbers relies on newly identified coelomocytes-the carotenocytes.Frontiers in immunology · 2025Article
- Comprehensive Review on Plant Cytochrome P450 Evolution: Copy Number, Diversity, and Motif Analysis From Chlorophyta to Dicotyledoneae.Genome biology and evolution · 2024Review
- Evolutionary history of the cytochrome P450s from Colletotrichum species and prediction of their putative functional roles during host-pathogen interactions.BMC genomics · 2024Article
- Multiple Routes to Color Convergence in a Radiation of Neotropical Poison Frogs.Systematic biology · 2023Article
- Astaxanthin: Past, Present, and Future.Marine drugs · 2023Review
- A salivary GMC oxidoreductase of Manduca sexta re-arranges the green leaf volatile profile of its host plant.Nature communications · 2023Article
- Intraspecific diversity in the mechanisms underlying abamectin resistance in a cosmopolitan pest.Evolutionary applications · 2023Article
- Biology of Two-Spotted Spider Mite (International journal of molecular sciences · 2023Article
- Carotenoid modifying enzymes in metazoans.Methods in enzymology · 2022Article
- Circadian and Neuroendocrine Basis of Photoperiodism Controlling Diapause in Insects and Mites: A Review.Frontiers in physiology · 2022Review
- The G126S substitution in mitochondrially encoded cytochrome b does not confer bifenazate resistance in the spider mite Tetranychus urticae.Experimental & applied acarology · 2021Article
- Adaptive divergence and post-zygotic barriers to gene flow between sympatric populations of a herbivorous mite.Communications biology · 2021Article
- Elucidation of the whole carotenoid biosynthetic pathway of aphids at the gene level and arthropodal food chain involving aphids and the red dragonfly.BMC zoology · 2021Article
- High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated with cytochrome P450-mediated detoxification in a generalist arthropod pest.PLoS genetics · 2021Article
- Article
- Evidence for hybrid breakdown in production of red carotenoids in the marine invertebrate Tigriopus californicus.PloS one · 2021Article
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Authors and funding
10 authors at 4 institutions in 4 countries.
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Abstract
Keto-carotenoids contribute to many important traits in animals, including vision and coloration. In a great number of animal species, keto-carotenoids are endogenously produced from carotenoids by carotenoid ketolases. Despite the ubiquity and functional importance of keto-carotenoids in animals, the underlying genetic architectures of their production have remained enigmatic. The body and eye colorations of spider mites (Arthropoda: Chelicerata) are determined by β-carotene and keto-carotenoid derivatives. Here, we focus on a carotenoid pigment mutant of the spider mite Tetranychus kanzawai that, as shown by chromatography, lost the ability to produce keto-carotenoids. We employed bulked segregant analysis and linked the causal locus to a single narrow genomic interval. The causal mutation was fine-mapped to a minimal candidate region that held only one complete gene, the cytochrome P450 monooxygenase CYP384A1, of the CYP3 clan. Using a number of genomic approaches, we revealed that an inactivating deletion in the fourth exon of CYP384A1 caused the aberrant pigmentation. Phylogenetic analysis indicated that CYP384A1 is orthologous across mite species of the ancient Trombidiformes order where carotenoids typify eye and body coloration, suggesting a deeply conserved function of CYP384A1 as a carotenoid ketolase. Previously, CYP2J19, a cytochrome P450 of the CYP2 clan, has been identified as a carotenoid ketolase in birds and turtles. Our study shows that selection for endogenous production of keto-carotenoids led to convergent evolution, whereby cytochrome P450s were independently co-opted in vertebrate and invertebrate animal lineages.
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