Evidence map›Paper›PMID 31311414›Full record

ArticleJournal of neurotrauma2020

Dynamic Thermal Mapping of Localized Therapeutic Hypothermia in the Brain.

John J Walsh, Yuegao Huang, John W Simmons, James A Goodrich, Brian McHugh, Douglas L Rothman, John A Elefteriades, Fahmeed Hyder, Daniel Coman

Abstract read
In one paragraph

Article in Journal of neurotrauma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Targeted temperature management and early neuro-prognostication after cardiac arrest.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

John J WalshDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut.
Yuegao HuangDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
John W SimmonsCoolSpine LLC, Woodbury, Connecticut.
James A GoodrichDepartment of Comparative Medicine, Yale University, New Haven, Connecticut.
Brian McHughDepartment of Neurosurgery, Yale University, New Haven, Connecticut.
Douglas L RothmanDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut.
John A ElefteriadesAortic Institute, Yale University, New Haven, Connecticut.
Fahmeed HyderDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut.
Daniel ComanDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
NeurophysiologicP30NS052519 · NINDS · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2007 to 2017
$6.7M
Extracellular pH mapping as therapeutic readout of drug delivery in glioblastomaR01EB023366 · NIBIB · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2017 to 2020
$2.5M
Translation of smart contrast agents for brain tumor characterization by MRR01CA140102 · NCI · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2010 to 2014
$1.6M
Multivalent PARACEST agents for quantitative molecular imagingR01EB011968 · NIBIB · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2010 to 2013
$1.3M
NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA140102NIBIB NIH HHS R01 EB011968NIBIB NIH HHS R01 EB023366NIGMS NIH HHS T32 GM007205NINDS NIH HHS P30 NS052519
6 · The paper itself

Abstract

Although whole body cooling is used widely to provide therapeutic hypothermia for the brain, there are undesirable clinical side effects. Selective brain cooling may allow for rapid and controllable neuroprotection while mitigating these undesirable side effects. We evaluated an innovative cerebrospinal fluid (CSF) cooling platform that utilizes chilled saline pumped through surgically implanted intraventricular catheters to induce hypothermia. Magnetic resonance thermal imaging of the healthy sheep brain (

Indexed as

BrainInfusions, IntraventricularAnimalsHypothermia, InducedMagnetic Resonance SpectroscopyMaleModels, AnimalSaline SolutionSheepThermographySaline SolutionbrainMRSselective coolingtemperature mappingtherapeutic hypothermia

Identifiers

PMID31311414
PMCPMC6922066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.