Evidence map›Paper›PMID 31311306›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Cilantro leaf harbors a potent potassium channel-activating anticonvulsant.

Rían W Manville, Geoffrey W Abbott

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Polymodal KCommunications biology · 2024
    Article
  5. Article
  6. Molecules (Basel, Switzerland) · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. KCNQ5 activation by tannins mediates vasorelaxant effects of barks used in Native American botanical medicine.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  11. Article
  12. Article
  13. KCNQ Potassium Channels as Targets of Botanical Folk Medicines.Annual review of pharmacology and toxicology · 2022
    Review
  14. Review
  15. KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2021
    Article
  16. Article
  17. Review
  18. Article
  19. Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine.The Journal of pharmacology and experimental therapeutics · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rían W ManvilleBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California-Irvine, Irvine, California, USA.
Geoffrey W AbbottBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California-Irvine, Irvine, California, USA.
University of California, Irvine · US

Funding

Ion Channel Transporter InteractionsR35GM130377 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Geoffrey W Abbott · 2019 to 2026
$4.0M
Therapeutic small molecule modulation of Kv channelsR01NS107671 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Geoffrey W Abbott · 2019 to 2026
$3.1M
Ion channel-transporter interactionsR01GM115189 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ABBOTT, GEOFFREY W · 2015 to 2018
$1.1M
NIGMS NIH HHS R01 GM115189NIGMS NIH HHS R35 GM130377NINDS NIH HHS R01 NS107671
6 · The paper itself

Abstract

Herbs have a long history of use as folk medicine anticonvulsants, yet the underlying mechanisms often remain unknown. Neuronal voltage-gated potassium channel subfamily Q (KCNQ) dysfunction can cause severe epileptic encephalopathies that are resistant to modern anticonvulsants. Here we report that cilantro (

Indexed as

AnimalsAnticonvulsantsBinding SitesCoriandrumKCNQ Potassium ChannelsMutagenesisNeuronsPlant LeavesXenopus laevisAnticonvulsantsKCNQ Potassium Channelsepilepsyherbal medicineKCNQ1KCNQ2KCNQ3

Identifiers

PMID31311306
PMCPMC6766653
OpenAlexW2959190828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.