Evidence map›Paper›PMID 31311103›Full record

ArticleInternational journal of molecular sciences2019

Molecular Docking and Molecular Dynamics Studies on Selective Synthesis of α-Amyrin and β-Amyrin by Oxidosqualene Cyclases from

Zhixue Wu, Hui Xu, Meiling Wang, Ruoting Zhan, Weiwen Chen, Ren Zhang, Zaoyuan Kuang, Fengxue Zhang, Kui Wang, Jiangyong Gu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Zhixue WuResearch Centre for Integrative Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Hui XuResearch Centre of Chinese Herbal Resource Science and Engineering, Guangzhou University of Chinese Medicine, Key Laboratory of Chinese Medicinal Resource from Lingnan (Guangzhou University of Chinese Medicine), Ministry of Education, Joint Laboratory of National Engineering Research Centre for the Pharmaceutics of Traditional Chinese Medicines, Guangzhou 510006, China.
Meiling WangResearch Centre of Chinese Herbal Resource Science and Engineering, Guangzhou University of Chinese Medicine, Key Laboratory of Chinese Medicinal Resource from Lingnan (Guangzhou University of Chinese Medicine), Ministry of Education, Joint Laboratory of National Engineering Research Centre for the Pharmaceutics of Traditional Chinese Medicines, Guangzhou 510006, China.
Ruoting ZhanResearch Centre of Chinese Herbal Resource Science and Engineering, Guangzhou University of Chinese Medicine, Key Laboratory of Chinese Medicinal Resource from Lingnan (Guangzhou University of Chinese Medicine), Ministry of Education, Joint Laboratory of National Engineering Research Centre for the Pharmaceutics of Traditional Chinese Medicines, Guangzhou 510006, China.
Weiwen ChenResearch Centre of Chinese Herbal Resource Science and Engineering, Guangzhou University of Chinese Medicine, Key Laboratory of Chinese Medicinal Resource from Lingnan (Guangzhou University of Chinese Medicine), Ministry of Education, Joint Laboratory of National Engineering Research Centre for the Pharmaceutics of Traditional Chinese Medicines, Guangzhou 510006, China.
Ren ZhangDepartment of Medical Biotechnology, College of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Zaoyuan KuangResearch Centre for Integrative Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Fengxue ZhangResearch Centre for Integrative Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Kui WangResearch Centre of Chinese Herbal Resource Science and Engineering, Guangzhou University of Chinese Medicine, Key Laboratory of Chinese Medicinal Resource from Lingnan (Guangzhou University of Chinese Medicine), Ministry of Education, Joint Laboratory of National Engineering Research Centre for the Pharmaceutics of Traditional Chinese Medicines, Guangzhou 510006, China. uk0829@126.com.ORCID 0000-0002-9540-8142
Jiangyong GuThe Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. gujy@gzucm.edu.cn.
Guangzhou University of Chinese Medicine · CN

Funding

Fostering Talents in Basic Science of the National Natural Science Foundation of China J1310017Guangdong Innovative Research Team Program 2016KYTD02Innovation team project of the Education Bureau of Guangdong Province-Research team on innovation of traditional Chinese medicine resources 2016KCXTD015National Natural Science Foundation of China 31802099 and 81804111Natural Science Foundation of Guangdong Province, China 2018A030310497Projects of Guangzhou University of Chinese Medicine A1-AFD018161Z0105, A1-AFD018171Z11016 & A1-AFD01817111013start-up support for scientific research of Xinglin Young Scholar in Guangzhou University of Chinese Medicine A1-AFD018161Z04Young Innovative Talents in Higher Education Institutions of Guangdong Province 2017KQNCX037
6 · The paper itself

Abstract

Amyrins are the immediate precursors of many pharmaceutically important pentacyclic triterpenoids. Although various amyrin synthases have been identified, little is known about the relationship between protein structures and the constituent and content of the products. IaAS1 and IaAS2 identified from

Indexed as

Molecular Docking SimulationBinding SitesIlexIntramolecular TransferasesOleanolic AcidPentacyclic TriterpenesPlant ProteinsProtein Bindingalpha-amyrinbeta-amyrinIntramolecular Transferaseslanosterol synthaseOleanolic AcidPentacyclic TriterpenesPlant Proteinsamyrinmolecular modelingoxidosqualene cyclaseresidue-product interactionselective synthesis

Identifiers

PMID31311103
PMCPMC6678101
OpenAlexW2961471331

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.