Observational studyJournal of cardiovascular electrophysiology2019
His bundle pacing, learning curve, procedure characteristics, safety, and feasibility: Insights from a large international observational study.
Observational study in Journal of cardiovascular electrophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04749836 (Registry of His Bundle, Bachmann Bundle and Left Bundle Branch Area Pacing for Various Pacing Indications), which is not on this map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Registry of His Bundle, Bachmann Bundle and Left Bundle Branch Area Pacing for Various Pacing Indications
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Success and complication rates of conduction system pacing: a meta-analytical observational comparison of left bundle branch area pacing and His bundle pacing.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Pooled it
- Conduction system pacing in prosthetic heart valves.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Pooled it
- Conduction system pacing, a European survey: insights from clinical practice.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Trial
- Effects of haemodynamically atrio-ventricular optimized His bundle pacing on heart failure symptoms and exercise capacity: the His Optimized Pacing Evaluated for Heart Failure (HOPE-HF) randomized, double-blind, cross-over trial.European journal of heart failure · 2023Trial
- Pediatric Pacing from Proximal Right Ventricular Septum: Preserved Left Ventricular Systolic Function at Follow-Up.Pediatric cardiology · 2026Article
- Permanent LEft ventricular septAl Pacing vs. right ventricular pacing in patients with atrioventricular conduction disorders-a randomized trial: rationale and design of the LEAP trial.European heart journal open · 2026Article
- Physiological pacing: just a lot of buzz or the next paradigm shift in bradycardia pacing?Singapore medical journal · 2026Review
- Preferences of Patients and Cardiologists Regarding Pacemaker Characteristics in Spain: A Discrete Choice Experiment.Patient preference and adherence · 2026Article
- Managing Bradycardia in Patients After Transcatheter Tricuspid Valve Replacement.Structural heart : the journal of the Heart Team · 2025Review
- Physiological pacing: mechanisms, clinical indications, and perspectives.European heart journal · 2025Review
- Early Deterioration of the Right Ventricular Pacing Threshold Predicts the Increase in His-Bundle Pacing Threshold During the Chronic Phase: A Single-Center Retrospective Study.Journal of arrhythmia · 2025Article
- Apex vs. Septum Pacing: A Comprehensive Review of Pacemaker Implantation Strategies.Biomedicines · 2025Review
- European Society of Cardiology (ESC) clinical consensus statement on indications for conduction system pacing, with special contribution of the European Heart Rhythm Association of the ESC and endorsed by the Asia Pacific Heart Rhythm Society, the Canadian Heart Rhythm Society, the Heart Rhythm Society, and the Latin American Heart Rhythm Society.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Adoption of left bundle branch area pacing using stylet-driven lead in a tertiary academic training center: Learning curve and acute procedural outcomes.Heart rhythm O2 · 2025Article
- Gender Differences for His Bundle Pacing Long-Term Performance in the Elderly Population.Journal of cardiovascular development and disease · 2025Article
- His Bundle Pacing in the Era of Left Bundle Branch Pacing.Arrhythmia & electrophysiology review · 2025Review
- Current Advance, Challenges and Future Perspectives of Conduction System Pacing.Reviews in cardiovascular medicine · 2024Review
- Long-Term Outcomes in Patients With Relatively High His-Bundle Capture Threshold After Permanent His-Bundle Pacing - A Multicenter Clinical Study.Circulation reports · 2024Article
- Conduction System Pacing: Hope, Challenges, and the Journey Forward.Current cardiology reports · 2024Review
- Current Role of Conduction System Pacing in Patients Requiring Permanent Pacing.Korean circulation journal · 2024Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
backgroundHis-bundle pacing (HBP) provides physiological ventricular activation. Observational studies have demonstrated the techniques' feasibility; however, data have come from a limited number of centers.
objectivesWe set out to explore the contemporary global practice in HBP focusing on the learning curve, procedural characteristics, and outcomes.
methodsThis is a retrospective, multicenter observational study of patients undergoing attempted HBP at seven centers. Pacing indication, fluoroscopy time, HBP thresholds, and lead reintervention and deactivation rates were recorded. Where centers had systematically recorded implant success rates from the outset, these were collated.
resultsA total of 529 patients underwent attempted HBP during the study period (2014-19) with a mean follow-up of 217 ± 303 days. Most implants were for bradycardia indications. In the three centers with the systematic collation of all attempts, the overall implant success rate was 81%, which improved to 87% after completion of 40 cases. All seven centers reported data on successful implants. The mean fluoroscopy time was 11.7 ± 12.0 minutes, the His-bundle capture threshold at implant was 1.4 ± 0.9 V at 0.8 ± 0.3 ms, and it was 1.3 ± 1.2 V at 0.9 ± 0.2 ms at last device check. HBP lead reintervention or deactivation (for lead displacement or rise in threshold) occurred in 7.5% of successful implants. There was evidence of a learning curve: fluoroscopy time and HBP capture threshold reduced with greater experience, plateauing after approximately 30-50 cases.
conclusionWe found that it is feasible to establish a successful HBP program, using the currently available implantation tools. For physicians who are experienced at pacemaker implantation, the steepest part of the learning curve appears to be over the first 30-50 cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.