ArticleJournal of cardiovascular electrophysiology2019
Consequences of chronic frequent premature atrial contractions: Association with cardiac arrhythmias and cardiac structural changes.
Article in Journal of cardiovascular electrophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Risk factors for the development of premature ventricular complex-induced cardiomyopathy: a systematic review and meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Pooled it
- Outcomes of Premature Ventricular Contraction-Cardiomyopathy in the Veteran Population: A Secondary Analysis of the CHF-STAT Study.JACC. Clinical electrophysiology · 2021Trial
- Atrial Septal Aneurysms: The Heart's Hidden Bulge.Acta Cardiologica Sinica · 2026Review
- Portable Holter with Cloud-Based Learning Analytics for Real-Time Health Monitoring.Journal of biomedical physics & engineering · 2025Article
- Smartwatch-enabled early detection and treatment of cardiomyopathy induced by premature atrial contractions: a case report.European heart journal. Case reports · 2025Article
- Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics - 2024 update.The Journal of physiology · 2025Review
- Blocked Atrial Bigeminy as an Unusual Cause of Bradycardia: A Case Report.International medical case reports journal · 2025Article
- Mechanisms of adaptive hypertrophic cardiac remodeling in a large animal model of premature ventricular contraction-induced cardiomyopathy.IUBMB life · 2023Article
- Impact of common rhythm disturbances on echocardiographic measurements and interpretation.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Review
- Extrasystoles or short bradycardias of the newborn seldom require subsequent 24-hour electrocardiographic monitoring.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Atrial and ventricular cardiomyopathy associated with premature atrial contractions: Speckle-tracking echocardiography demonstrates reversibility following successful ablation.HeartRhythm case reports · 2022Article
- Left ventricular dyssynchrony as marker of early dysfunction in premature ventricular contraction-induced cardiomyopathy.Frontiers in cardiovascular medicine · 2022Article
- Mapping and Ablation of Isolated Frequent Symptomatic Premature Atrial Contractions in Patients With Structurally Normal Heart.Frontiers in cardiovascular medicine · 2022Article
- Relatively Benign yet a Reversible Cause of Dilated Cardiomyopathy.JACC. Case reports · 2021Article
- Ectopic Burden via Holter Monitors in Friedreich Ataxia.Pediatric neurology · 2021Observational
- Eccentric hypertrophy in an animal model of mid- and long-term premature ventricular contraction-induced cardiomyopathy.Heart rhythm O2 · 2021Article
- The Burden of Ventricular Premature Complex Is Associated With Cardiovascular Mortality.Frontiers in cardiovascular medicine · 2021Article
- Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice.Sensors (Basel, Switzerland) · 2020Article
- Premature atrial complex-induced cardiomyopathy: Case report and literature review.HeartRhythm case reports · 2020Article
- Clinical and translational insights on premature ventricular contractions and PVC-induced cardiomyopathy.Progress in cardiovascular diseasesReview
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
introductionFrequent premature ventricular contractions (PVCs) can cause cardiomyopathy (CM). Postextrasystolic potentiation (PESP) and irregularity have been in implicated as triggers of PVC-CM. Because both phenomena can also be found in premature atrial contractions (PACs), it is speculated that frequent PACs have similar consequences. METHODS AND
resultsA single-center, retrospective study included all consecutive patients undergoing a 14-day Holter monitors (November 2014 to October 2016). Patients were divided into four groups by ectopy burden group 1 (<1%) and remaining by tertiles (group 2-4). Echocardiographic and arrhythmic data were compared between PAC and PVC burdens. In addition, a translational PAC animal model was used to assess the chronic effects of frequent PACs. A total 846 patients were reviewed. In contrast to PVCs, we found no difference in left ventricular ejection fraction (LVEF), end-systolic and end-diastolic dimensions and presence of CM (LVEF <50%) between different PAC groups. Multivariate regression analysis demonstrated that only PVC burden predicted low EF (odds ratio, 1.1; confidence interval, 1.03-1.13; P = .001). While there was a weak correlation between PAC burden and supraventricular tachycardia (SVT) episodes and atrial fibrillation (AF) burden (r = 0.19; P < .001), there was no correlation between PAC burden and LVEF or CM. Finally, atrial bigeminy in our animal model did not significantly decrease LVEF after 3 months.
conclusionPAC burden is associated with increased AF and SVT episodes. In contrast to a high PVC burden, a high PAC burden is not associated with CM. Our findings suggest that heart rate irregularity and/or PESP may play a minimal role in the pathophysiology of PVC-CM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.