ArticleSocial cognitive and affective neuroscience2019
Irritability and brain volume in adolescents: cross-sectional and longitudinal associations.
Article in Social cognitive and affective neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Pooled it
- Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026Article
- Brain Age in Conduct Disorder:: A Mega-Analysis of the ENIGMA Antisocial Behavior Working Group.bioRxiv : the preprint server for biology · 2026Article
- Concurrent and longitudinal neurostructural correlates of irritability in children.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Neural mechanisms of inhibitory control in preadolescent irritability: Insights from the ABCD study.Biological psychology · 2024Article
- Observed Parenting and Adolescent Brain Structure.Developmental neuropsychology · 2023Article
- White matter integrity in adolescent irritability: A preliminary study.Psychiatry research. Neuroimaging · 2022Article
- Fine Particulate Air Pollution, Early Life Stress, and Their Interactive Effects on Adolescent Structural Brain Development: A Longitudinal Tensor-Based Morphometry Study.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- A Connectome-wide Functional Signature of Trait Anger.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- The relationship between adolescents' externalizing and internalizing symptoms and brain development over a period of three years.NeuroImage. Clinical · 2022Article
- Network-wise surface-based morphometric insight into the cortical neural circuitry underlying irritability in adolescents.Translational psychiatry · 2021Article
- Review
- Linking irritability and functional brain networks: A transdiagnostic case for expanding consideration of development and environment in RDoC.Neuroscience and biobehavioral reviews · 2021Review
- Structural atrophy of the right superior frontal gyrus in adolescents with severe irritability.Human brain mapping · 2021Article
- Structural Brain Development and Aggression: A Longitudinal Study in Late Childhood.Cognitive, affective & behavioral neuroscience · 2021Article
- Irritability Is Associated With Decreased Cortical Surface Area and Anxiety With Decreased Gyrification During Brain Development.Frontiers in psychiatry · 2021Article
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Authors and funding
5 authors.
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Abstract
Irritability is garnering increasing attention in psychiatric research as a transdiagnostic marker of both internalizing and externalizing disorders. These disorders often emerge during adolescence, highlighting the need to examine changes in the brain and in psychological functioning during this developmental period. Adolescents were recruited for a longitudinal study examining the effects of early life stress on the development of psychopathology. The 151 adolescents (73 M/78 F, average age = 11.5 years, standard deviation = 1.1) were scanned with a T1-weighted MRI sequence and parents completed reports of adolescent irritability using the Affective Reactivity Index. Of these 151 adolescents, 94 (46 M/48 F) returned for a second session (average interval = 1.9 years, SD = 0.4). We used tensor-based morphometry to examine cross-sectional and longitudinal associations between irritability and regional brain volume. Irritability was associated with brain volume across a number of regions. More irritable individuals had larger hippocampi, insula, medial orbitofrontal cortex and cingulum/cingulate cortex and smaller putamen and internal capsule. Across the brain, more irritable individuals also had larger volume and less volume contraction in a number of areas that typically decrease in volume over the developmental period studied here, suggesting delayed maturation. These structural changes may increase adolescents' vulnerability for internalizing and externalizing disorders.
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