ArticleSurgery today2019
Changes in the rate of and trends in colectomy for ulcerative colitis during the era of biologics and calcineurin inhibitors based on a Japanese nationwide cohort study.
Article in Surgery today, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Trial
- Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid-2026.Annals of gastroenterological surgery · 2026Review
- Clinicopathological features and cancer-specific survival in young patients with ulcerative colitis-associated colorectal neoplasia: a nationwide cohort study in Japan.Inflammatory bowel diseases · 2026Article
- Visualizing Paneth Cell Metaplasia: A Novel Approach to UC Endoscopic Cancer Surveillance.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Article
- Analysis of clinicopathological features and oncological outcomes of ulcerative colitis-associated colorectal cancer based on macroscopic classification.International journal of colorectal disease · 2025Article
- Twenty-Year Trends in Colectomy Rates and Advanced Therapy Prescribing in Lothian, Scotland.Alimentary pharmacology & therapeutics · 2025Article
- Colorectal Neoplasia in Inflammatory Bowel Disease.Cancers · 2025Review
- Genetic Analysis of Biopsy Tissues from Colorectal Tumors in Patients with Ulcerative Colitis.Cancers · 2024Article
- Associations between Pouchitis and Fecal Calprotectin after Restorative Proctocolectomy in Patients with Ulcerative Colitis.Inflammatory intestinal diseases · 2023Article
- Long-term prognosis and clinical practice for new-onset ulcerative colitis in the era of biologics: A Japanese retrospective study.JGH open : an open access journal of gastroenterology and hepatology · 2023Article
- Have advances in medical therapy for ulcerative colitis impacted surgical treatment?Annals of gastroenterological surgery · 2023Article
- A case of intestinal malrotation apparent after laparoscopically total proctocolectomy followed by ileal-pouch-anal anastomosis for ulcerative colitis.Asian journal of endoscopic surgery · 2023Article
- Surgical Management of Inflammatory Bowel Disease.Rhode Island medical journal (2013) · 2022Article
- Article
- Long Distance Between the Superior Mesenteric Artery Root and Bottom of the External Anal Sphincter Is a Risk Factor for Stoma Outlet Obstruction After Total Proctocolectomy and Ileal-Pouch Anal Anastomosis for Ulcerative Colitis.Annals of gastroenterological surgery · 2022Article
- Medical Therapy in Chronic Refractory Ulcerative Colitis: When Enough Is Enough.Clinics in colon and rectal surgery · 2022Review
- Analysis of the disease activity of ulcerative colitis with and without concomitant primary sclerosing cholangitis: An investigation using a nationwide database in Japan.JGH open : an open access journal of gastroenterology and hepatology · 2022Article
- Analysis of the Long-Term Prognosis in Japanese Patients with Ulcerative Colitis Treated with New Therapeutic Agents and the Correlation between Prognosis and Disease Susceptibility Loci.Inflammatory intestinal diseases · 2021Article
- Current status of IBD and surgery of Crohn's disease in Thailand.Annals of gastroenterological surgery · 2021Review
- Potential problems of partial resection for colitis-associated cancer in a patient with ulcerative colitis: case report.Journal of surgical case reports · 2021Article
Corrections and comments
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Authors and funding
32 authors.
Funding
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Abstract
purposeWe evaluated the recent incidence of surgery and the changing surgery trends for ulcerative colitis (UC) in Japan due to the increasing use of anti-tumor necrosis factor (TNF) agents.
methodsA questionnaire survey was performed to assess the number of surgeries, surgical indications, surgical timing, and immunosuppressive treatments before surgery between 2007 and 2017.
resultsA total of 3801 surgical cases were reported over 11 years. The prevalence of UC surgery decreased over the period studied. The rate of prednisolone (PSL) use did not change. The prevalence of both calcineurin inhibitors (CNIs) and anti-TNF agents increased during the period studied (p < 0.01). The prevalence of urgent/emergent surgery did not change. The most distinctive change in surgical indications was the increase in cancer/dysplasia (CAC), the prevalence of which increased from 20.2% in 2007 to 34.8%.
conclusionThe prevalence of UC surgery seems to be decreasing according to the increasing rate of anti-TNF agent and CNI administration. However, the indication of CAC significantly increased. Further research should evaluate whether or not long-term remission maintained with several agents can lead to increasing CAC.
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