Evidence map›Paper›PMID 31309281›Full record

ArticleEuropean journal of nutrition2020

Association of dietary nitrate intake with retinal microvascular structure in older adults.

Bamini Gopinath, Gerald Liew, Joshua R Lewis, Lauren C Blekkenhorst, Catherine Bondonno, George Burlutsky, Jonathan M Hodgson, Paul Mitchell

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In one paragraph

Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bamini GopinathCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Westmead, NSW, 2145, Australia. bamini.gopinath@sydney.edu.au.ORCID http://orcid.org/0000-0003-3573-359X
Gerald LiewCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Westmead, NSW, 2145, Australia.
Joshua R LewisCentre for Kidney Research, Westmead Institute for Medical Research, Westmead, NSW, 2145, Australia.
Lauren C BlekkenhorstSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Catherine BondonnoSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
George BurlutskyCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Westmead, NSW, 2145, Australia.
Jonathan M HodgsonSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Paul MitchellCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Westmead, NSW, 2145, Australia.
Edith Cowan University · AUThe University of Sydney · AU

Funding

Australian National Health and Medical Research Council 211069Australian National Health and Medical Research Council 262120Australian National Health and Medical Research Council 974159Australian National Health and Medical Research Council 991407
6 · The paper itself

Abstract

purposeExisting research suggests that changes to retinal vascular caliber reflect nitric oxide (NO)-dependent endothelial dysfunction. Dietary nitrate is an important source of NO; however, studies on the link between dietary nitrate intake and retinal microvasculature are lacking. We aimed to assess the cross-sectional association between intake of dietary nitrate (from vegetable and non-vegetable sources) and retinal arteriolar and venular caliber among older adults.

methodsParticipants from the Blue Mountains Eye Study aged 49+ years with complete data at baseline on diet and retinal vessel measures were analyzed (n = 2813). Dietary intake was assessed using a validated semi-quantitative food-frequency questionnaire. Nitrate intake from vegetable and non-vegetable sources was estimated using a validated comprehensive database and other published data where necessary. Fundus photographs were taken and retinal vascular caliber measured using validated computer-assisted techniques and summarized.

resultsParticipants in the lowest versus highest tertile of vegetable nitrate intake had significantly narrower retinal arterioles: 186.2 ± 0.48 versus 187.6 ± 0.48 µm (multivariable-adjusted p = 0.04). After multivariable adjustment, each 10-unit higher intake of total nitrate and vegetable nitrate was associated with 0.089 ± 0.004 and 0.090 ± 0.004 µm wider retinal arteriolar caliber, respectively, both p = 0.03. Each 10-unit higher vegetable nitrate intake was associated with 0.092 ± 0.005 µm narrower retinal venules (p = 0.05).

conclusionIntake of dietary nitrate, particularly from vegetable sources, was associated with beneficial variations in both retinal arteriolar and venular caliber among older adults. Further research into associations between dietary nitrate and the retinal microvasculature could allow for greater understanding and possible prevention of clinical cardiovascular events.

Indexed as

EatingNitratesAgedArteriolesCross-Sectional StudiesHumansVenulesNitratesBlue Mountains Eye StudyNitrateNitric oxideOlder adultsRetinal vascular caliber

Identifiers

PMID31309281
OpenAlexW2959048448

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.