Evidence map›Paper›PMID 31309147›Full record

ArticleScience advances2019

Imaging striatal dopamine release using a nongenetically encoded near infrared fluorescent catecholamine nanosensor.

Abraham G Beyene, Kristen Delevich, Jackson Travis Del Bonis-O'Donnell, David J Piekarski, Wan Chen Lin, A Wren Thomas, Sarah J Yang, Polina Kosillo, Darwin Yang, George S Prounis and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  11. Review
  12. Neurochemical imaging reveals changes in dopamine dynamics with photoperiod in a seasonally social vole species.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abraham G BeyeneDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-3896-2144
Kristen DelevichDepartment of Psychology, University of California, Berkeley, Berkeley, CA, USA.
Jackson Travis Del Bonis-O'DonnellDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-9135-2102
David J PiekarskiDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA.
Wan Chen LinDepartment of Psychology, University of California, Berkeley, Berkeley, CA, USA.
A Wren ThomasHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-6189-9038
Sarah J YangDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-5950-3006
Polina KosilloDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-1944-9460
Darwin YangDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA.
George S ProunisHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-3061-1534
Linda WilbrechtDepartment of Psychology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-3492-8141
Markita P LandryDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-5832-8522

Funding

Neuroscience Training Program at UC BerkeleyT32NS095939 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BATEUP, HELEN S. · 2016 to 2025
$6.3M
Optical montoring of modulatory neurotransmitter levels using new infrared nanonsensorsR21DA044010 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI WILBRECHT, LINDA E · 2017 to 2018
$323k
NIDA NIH HHS R21 DA044010NINDS NIH HHS T32 NS095939
6 · The paper itself

Abstract

Neuromodulation plays a critical role in brain function in both health and disease, and new tools that capture neuromodulation with high spatial and temporal resolution are needed. Here, we introduce a synthetic catecholamine nanosensor with fluorescent emission in the near infrared range (1000-1300 nm), near infrared catecholamine nanosensor (nIRCat). We demonstrate that nIRCats can be used to measure electrically and optogenetically evoked dopamine release in brain tissue, revealing hotspots with a median size of 2 µm. We also demonstrated that nIRCats are compatible with dopamine pharmacology and show D2 autoreceptor modulation of evoked dopamine release, which varied as a function of initial release magnitude at different hotspots. Together, our data demonstrate that nIRCats and other nanosensors of this class can serve as versatile synthetic optical tools to monitor neuromodulatory neurotransmitter release with high spatial resolution.

Indexed as

Biosensing TechniquesMolecular ImagingAnimalsCatecholaminesCorpus StriatumDopamineMiceNeuronsSpectroscopy, Near-InfraredSynaptic TransmissionCatecholaminesDopamine

Identifiers

PMID31309147
PMCPMC6620097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.