Evidence map›Paper›PMID 31309134›Full record

ArticleNeurobiology of stress2019

Sustained corticosterone rise in the prefrontal cortex is a key factor for chronic stress-induced working memory deficits in mice.

Gaelle Dominguez, Nadia Henkous, Thomas Prevot, Vincent David, Jean-Louis Guillou, Catherine Belzung, Nicole Mons, Daniel Béracochéa

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Corticosterone accelerates behavioral inflexibility via plasticity-related gene expression in the dorsal striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  4. Article
  5. Mitogen-activated protein kinase dependent presynaptic potentiation in the lateral habenula mediates depressive-like behaviors in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
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  13. Acute Normobaric Hypoxia Lowers Executive Functions among Young Men despite Increase of BDNF Concentration.International journal of environmental research and public health · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gaelle DominguezUniversité de Bordeaux, CNRS UMR 5287, 33615, Pessac, France.
Nadia HenkousUniversité de Bordeaux, CNRS UMR 5287, 33615, Pessac, France.
Thomas PrevotUniversité de Bordeaux, CNRS UMR 5287, 33615, Pessac, France.
Vincent DavidUniversité de Bordeaux, CNRS UMR 5287, 33615, Pessac, France.
Jean-Louis GuillouUniversité de Bordeaux, CNRS UMR 5287, 33615, Pessac, France.
Catherine BelzungUniversité François Rabelais, Inserm U930, Parc Grandmont, 37200, Tours, France.
Nicole MonsUniversité de Bordeaux, CNRS UMR 5287, 33615, Pessac, France.
Daniel BéracochéaUniversité de Bordeaux, CNRS UMR 5287, 33615, Pessac, France.
Centre National de la Recherche Scientifique · FRUniversité de Tours · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to prolonged, unpredictable stress leads to glucocorticoids-mediated long-lasting neuroendocrine abnormalities associated with emotional and cognitive impairments. Excessive levels of serum glucocorticoids (cortisol in humans, corticosterone in rodents) contribute notably to deficits in working memory (WM), a task which heavily relies on functional interactions between the medial prefrontal cortex (PFC) and the dorsal hippocampus (dHPC). However, it is unknown whether stress-induced increases in plasma corticosterone mirror corticosterone levels in specific brain regions critical for WM. After a 6 week-

Indexed as

GlucocorticoidsHippocampusPrefrontal cortexStressWorking memory

Identifiers

PMID31309134
PMCPMC6607320
OpenAlexW2934549210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.