Evidence map›Paper›PMID 31309077›Full record

ArticleAvicenna journal of phytomedicine

Earnest Oghenesuvwe Erhirhie, Chika Ndubuisi Emeghebo, Emmanuel Emeka Ilodigwe, Daniel Lotanna Ajaghaku, Blessing Ogechukwu Umeokoli, Peter Maduabuchi Eze, Kenneth Gerald Ngwoke, Festus Basden Gerald Chiedu Okoye

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 21 citations in OpenAlex.

  1. Antioxidants (Basel, Switzerland) · 2022
    Article
  2. Article
  3. Ca' Granda,Molecules (Basel, Switzerland) · 2021
    Article
  4. SephadexMolecules (Basel, Switzerland) · 2020
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Earnest Oghenesuvwe ErhirhieDepartment of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Chika Ndubuisi EmegheboDepartment of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Emmanuel Emeka IlodigweDepartment of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Daniel Lotanna AjaghakuDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Enugu State, Nigeria.
Blessing Ogechukwu UmeokoliDepartment of Pharmaceutical and Medicinal Chemistry Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Peter Maduabuchi EzeDepartment of Pharmaceutical Biology and Biotechnology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Kenneth Gerald NgwokeDepartment of Pharmaceutical and Medicinal Chemistry Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Festus Basden Gerald Chiedu OkoyeDepartment of Pharmaceutical and Medicinal Chemistry Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Nnamdi Azikiwe University · NGEnugu State University of Science and Technology · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMATERIALS AND

methodsThe ethanolic leaf extract and fractions were screened for anti-inflammatory properties using egg-albumin-induced paw edema, xylene-induced topical ear edema, formaldehyde-induced arthritis and ulcerogenic models. The ethyl acetate most promising vacuum liquid chromatography fraction (VLC-E7) was purified using size exclusion chromatography technique (Sephadex LH-20) and its structure was elucidated using nuclear magnetic resonance (NMR) and mass spectrometry. Total phenolic and flavonoid contents were also determined.

resultsFrom the study, ethyl acetate and butanol fractions elicited better anti-inflammatory activities in egg-albumin-induced paw edema, formaldehyde-induced arthritis and xylene-induced topical ear edema. The ethanol extract, ethyl acetate and butanol fractions were non-ulcerogenic at 200 and 400 mg/kg. The compound isolated from Sephadex fraction (SPH-E6) was quercetin-3-O-α-L-rhamnopyranoside.

conclusionResults of this study justify the ethnomedicinal use of

Indexed as

Anti-inflammatoryDryopteris filix-masNon-ulcerogenicQuercetin 3-O-α-L-rhamnopyranosideRheumatoid arthritis

Identifiers

PMID31309077
PMCPMC6612247
OpenAlexW2946049983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.