Evidence map›Paper›PMID 31308836›Full record

ArticleJournal of geriatric cardiology : JGC2019

Calcium channel blocker monotherapy versus combination with renin-angiotensin system inhibitors on the development of new-onset diabetes mellitus in hypertensive Korean patients.

Yong Hoon Kim, Ae-Young Her, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Yoonjee Park, Dong Oh Kang, Won Young Jang, Woohyeun Kim and 9 more

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In one paragraph

Article in Journal of geriatric cardiology : JGC, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yong Hoon KimDivision of Cardiology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, South Korea.
Ae-Young HerDivision of Cardiology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, South Korea.
Seung-Woon RhaCardiovascular Center, Korea University Guro Hospital, Seoul, South Korea.
Byoung Geol ChoiCardiovascular Center, Korea University Guro Hospital, Seoul, South Korea.
Se Yeon ChoiDepartment of Medicine, Korea University Graduate School, Seoul, South Korea.
Jae Kyeong ByunDepartment of Medicine, Korea University Graduate School, Seoul, South Korea.
Yoonjee ParkCardiovascular Center, Korea University Guro Hospital, Seoul, South Korea.
Dong Oh KangCardiovascular Center, Korea University Guro Hospital, Seoul, South Korea.
Won Young JangCardiovascular Center, Korea University Guro Hospital, Seoul, South Korea.
Woohyeun KimCardiovascular Center, Korea University Guro Hospital, Seoul, South Korea.
Woong Gil ChoiCardiology Department, Konkuk University Chungju Hospital, Chungju, South Korea.
Tae Soo KangDepartment of Internal Medicine, Cardiovascular Division, Dankook University Hospital, Cheonan, South Korea.
Jihun AhnDepartment of Cardiology, Soonchunhyang University Gumi Hospital, Gumi, South Korea.
Sang-Ho ParkCardiology Department, Soonchunhyang University Cheonan Hospital, Cheonan, South Korea.
Ji Young ParkDivision of Cardiology, Department of Internal Medicine, Cardiovascular Center, Nowon Eulji Medical Center, Eulji University, Seoul, South Korea.
Min-Ho LeeDepartment of Cardiology, Soonchunhyang University College of Medicine, Seoul, South Korea.
Cheol Ung ChoiCardiovascular Center, Korea University Guro Hospital, Seoul, South Korea.
Chang Gyu ParkCardiovascular Center, Korea University Guro Hospital, Seoul, South Korea.
Hong Seog SeoCardiovascular Center, Korea University Guro Hospital, Seoul, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn real practice, two or more antihypertensive drugs are needed to achieve target blood pressure. We investigated the comparative beneficial actions of combination therapy of renin-angiotensin system inhibitors (RASI), with calcium channel blockers (CCB) over CCB monotherapy on the development of new-onset diabetes mellitus (NODM) in Korean patients during four-year follow-up periods.

methodsA total of 3208 consecutive hypertensive patients without a history of diabetes mellitus who had been prescribed CCB were retrospectively enrolled from January 2004 to December 2012. These patients were divided into the two groups according to the additional use of RASI (the RASI group,

resultsAfter propensity score-matched (PSM) analysis, two propensity-matched groups (939 pairs,

conclusionsThe use of RASI in addition to CCB showed comparable incidences of NODM and MACE compared to CCB monotherapy in non-diabetic hypertensive Korean patients during four-year follow-up period. However, large-scaled randomized controlled clinical trials will be required for a more definitive conclusion.

Indexed as

Calcium channel blockerDiabetes mellitusRenin-angiotensin system inhibitors

Identifiers

PMID31308836
PMCPMC6612608

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.