ArticleJournal of ginseng research2019
Dammarane-type triterpene oligoglycosides from the leaves and stems of
Article in Journal of ginseng research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Boosting the catalytic efficiency of UGT51 for efficient production of rare ginsenoside Rh2.Folia microbiologica · 2025Article
- Research on the synergistic prediction of the suitable distribution and chemical components of Panax Notoginseng under the background of climate warming.BMC plant biology · 2025Article
- Pharmacological and therapeutic effects of natural products on liver regeneration-a comprehensive research.Chinese medicine · 2025Review
- A narrative review ofJournal of ginseng research · 2025Review
- Coordinated gene expression and hormonal fluxes dictating ginsenoside Rb3 biosynthesis in floral development of Panax notoginseng.BMC plant biology · 2025Article
- Optimization of saponin extraction from the leaves ofFood chemistry: X · 2024Article
- The Optimization Design of Macrophage Membrane Camouflaging Liposomes for Alleviating Ischemic Stroke Injury through Intranasal Delivery.International journal of molecular sciences · 2024Article
- Self-Double-Emulsifying Drug Delivery System Enteric-Coated Capsules: A Novel Approach to Improve Oral Bioavailability and Anti-inflammatory Activity of Panax notoginseng Saponins.AAPS PharmSciTech · 2023Article
- Chemical Characterization and Metabolic Profiling of the Compounds in the Chinese Herbal Formula Li Chang Decoction by UPLC-QTOF/MS.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- An instant beverage rich in nutrients and secondary metabolites manufactured from stems and leaves ofFrontiers in nutrition · 2022Article
- Ginsenosides inActa pharmaceutica Sinica. B · 2021Review
- Antidiabetic Flavonoids from Fruits ofPharmaceutics · 2021Article
- Identification of Bioactive Natural Product from the Stems and Stem Barks ofPharmaceutics · 2021Article
- Evaluation of Anti-inflammatory Nutraceuticals in LPS-induced Mouse Neuroinflammation Model: An Update.Current neuropharmacology · 2020Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammation is widespread in the clinical pathology and closely associated to the progress of many diseases. Triterpenoid saponins as a key group of active ingredients in
methodsSilica gel and reversed-phase C8 column chromatography were used. Furthermore, preparative HPLC was used as a final purification technique to obtain minor saponins with high purities. MS, NMR experiments, and chemical methods were used in the structural identifications. The antiinflammatory activities of the isolated saponins were assessed by measuring the nitric oxide production in RAW 264.7 cells stimulated by lipopolysaccharides. Real-time reverse transcription polymerase chain reaction was used to measure the gene expressions of inflammation-related gene.
resultsEight new minor dammarane-type triterpene oligoglycosides, namely notoginsenosides LK1-LK8 (1-8) were obtained from PNLS, along with seven known ones. Among the isolated saponins, gypenoside IX significantly suppressed the nitric oxide production and inflammatory cytokines including tumor necrosis factor-α, interleukin 10, interferon-inducible protein 10 and interleukin-1β.
conclusionThe eight saponins may enrich and expand the chemical library of saponins in
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