ArticleInfection and drug resistance2019
Usefulness of serum D‑dimer for preoperative diagnosis of infected nonunion after open reduction and internal fixation.
Article in Infection and drug resistance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Association between fibrinogen concentration and nonunion in fracture patients.Frontiers in surgery · 2026Article
- Fracture related Infection - Challenges in definition and diagnosis.Journal of orthopaedics · 2024Article
- Current Concepts of Fracture-Related Infection.International journal of clinical practice · 2023Review
- Combination of albumin-to-globulin ratio and plasma fibrinogen is a sensitive tool for preoperative screening of infected nonunion in patients undergoing reoperation after open reduction and internal fixation: a retrospective study.Journal of orthopaedic surgery and research · 2022Article
- Diagnostic value of platelet indices in infected nonunion: a retrospective study.Journal of orthopaedic surgery and research · 2022Article
- A bibliometric analysis of clinical research on fracture-related infection.BioMed research international · 2022Article
- Plasma d-Dimer Levels in Non-prosthetic Orthopaedic Implant Infection: Can it Aid Diagnosis?Indian journal of orthopaedics · 2020Article
- Plasma Fibrinogen as a Diagnostic Marker of Infection in Patients with Nonunions.Infection and drug resistance · 2020Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeInfected nonunion after open reduction internal fixation (ORIF) is a serious complication. The aim of this study was to evaluate the usefulness of serum D-dimer for preoperative diagnosis of infected nonunion. PATIENTS AND
methodsPatients undergoing debridement and external fixation for infected nonunion (n=32) and replacement of internal fixation due to aseptic failure (n=34) were enrolled and compared in this retrospective study. The optimum cutoff value of D-dimer for identification of infected nonunion was determined by calculating the Youden J statistic. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of four preoperative laboratory parameters-serum D-dimer level, white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP)-for diagnosis of infected nonunion were compared.
resultsSerum D-dimer level was significantly higher in patients with infected nonunion than in patients with aseptic nonunion: 2.62 mg/mL (range, 0.13-11.90 mg/mL) vs 0.35 mg/mL (range, 0.07-6.46 mg/mL;
conclusionsSerum D-dimer level may be useful for preoperative prediction of infected nonunion in patients after ORIF.
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