Trial reportInternational journal of chronic obstructive pulmonary disease2019
Nasal high-flow versus noninvasive ventilation in patients with chronic hypercapnic COPD.
Trial report in International journal of chronic obstructive pulmonary disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Respiratory Support in the Emergency Department: An Updated Systematic Review and Meta-Analysis.Worldviews on evidence-based nursing · 2026Pooled it
- Implementation of long-term noninvasive positive airway pressure therapy in patients with COPD: a systematic review and meta-analysis of acceptance and adherence.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Efficacy of non-invasive ventilation in chronic obstructive pulmonary disease management: a systematic review and meta-analysis of randomized controlled trials.BMC pulmonary medicine · 2025Pooled it
- Home Respiratory Strategies in Patients With COPD With Chronic Hypercapnic Respiratory Failure.Respiratory care · 2024Pooled it
- Comparison of High Flow Nasal Therapy with Non-Invasive Ventilation and Conventional Oxygen Therapy for Acute Hypercapnic Respiratory Failure: A Meta-Analysis of Randomized Controlled Trials.International journal of chronic obstructive pulmonary disease · 2023Pooled it
- The efficacy and safety of high-flow nasal cannula therapy in patients with COPD and type II respiratory failure: a meta-analysis and systematic review.European journal of medical research · 2021Pooled it
- Efficiency of High-Flow Nasal Cannula on Pulmonary Rehabilitation in COPD Patients: A Meta-Analysis.BioMed research international · 2020Pooled it
- Bronchodilator Efficacy of High-Flow Nasal Cannula in COPD: Vibrating Mesh Nebulizer Versus Jet Nebulizer.Respiratory care · 2024Trial
- Development in PaCOBMJ open respiratory research · 2020Trial
- Home High-Flow Nasal Cannula Oxygen Therapy in a Chronic Obstructive Pulmonary Disease Patient with Chronic Stable Hypoxemic and Hypercapnic Respiratory Failure.Tuberculosis and respiratory diseases · 2026Article
- ERS Congress 2025: highlights from the Respiratory Intensive Care Assembly.ERJ open research · 2026Article
- Management of hypercapnic acute respiratory failure with high-flow nasal cannula therapy: A narrative review.Annals of intensive care · 2026Review
- Home High-Flow Nasal Cannula in Patients with Chronic Respiratory Failure: A Literature Review and Suggestions for Clinical Practice.Tuberculosis and respiratory diseases · 2025Article
- The impact of different prong-nares ratio on ventilation in COPD patients using nasal high-flow (NHF) - a physiological study.BMC pulmonary medicine · 2024Article
- Comparing Highs and Flows in Patients With COPD With Chronic Hypercapnic Respiratory Failure.Respiratory care · 2024Article
- Highlights from the Respiratory Failure and Mechanical Ventilation Conference 2024.Breathe (Sheffield, England) · 2024Article
- Effect of Nasal High Flow (NHF) on Right Heart Function in Stable Patients with Pulmonary Hypertension of Different WHO Classes.Journal of clinical medicine · 2024Article
- Article
- Home High-Flow Therapy in Patients with Chronic Respiratory Diseases: Physiological Rationale and Clinical Results.Journal of clinical medicine · 2023Review
- High-Flow Nasal Cannula versus Noninvasive Ventilation in AECOPD Patients with Respiratory Acidosis: A Retrospective Propensity Score-Matched Study.Canadian respiratory journal · 2023Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Despite the encouraging results of noninvasive ventilation (NIV) in chronic hypercapnic COPD patients, it is also evident that some patients do not tolerate NIV or do not benefit from it. We conducted a study in which COPD patients with stable, chronic hypercapnia were treated with NIV and nasal high-flow (NHF) to compare effectiveness. Methods: In a multi-centered, randomized, controlled, cross-over design, patients received 6 weeks of NHF ventilation followed by 6 weeks of NIV ventilation or vice-versa (TIBICO) between 2011 and 2016. COPD patients with stable daytime hypercapnia (pCO Results: A total of 102 patients (mean±SD) age 65.3±9.3 years, 61% females, body mass index 23.1±4.8 kg/m Conclusions: NHF may constitute an alternative to NIV in COPD patients with stable chronic hypercapnia, eg, those not tolerating or rejecting NIV with respect to pCO
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