Evidence map›Paper›PMID 31308628›Full record

ArticleDrug design, development and therapy2019

Novel peptide myristoly-CM4 induces selective cytotoxicity in leukemia K562/MDR and Jurkat cells by necrosis and/or apoptosis pathway.

Huidan Zhang, Dongju Han, Tongtong Lv, Kehang Liu, Yunqing Yang, Xixi Xu, Yuqing Chen

Abstract read
In one paragraph

Article in Drug design, development and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Enhancement of antitumor activity through structural optimization of 2-(Benzylamino)-thieno[2,3-d]pyrimidin-4(3H)-ones.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huidan Zhang *Department of Biochemistry, Life Sciences College, Nanjing Normal University, Nanjing, People's Republic of China.
Dongju Han *Department of Biochemistry, Life Sciences College, Nanjing Normal University, Nanjing, People's Republic of China.
Tongtong LvDepartment of Biochemistry, Life Sciences College, Nanjing Normal University, Nanjing, People's Republic of China.
Kehang LiuDepartment of Biochemistry, Life Sciences College, Nanjing Normal University, Nanjing, People's Republic of China.
Yunqing YangDepartment of Biochemistry, Life Sciences College, Nanjing Normal University, Nanjing, People's Republic of China.
Xixi XuDepartment of Biochemistry, Life Sciences College, Nanjing Normal University, Nanjing, People's Republic of China.
Yuqing ChenDepartment of Biochemistry, Life Sciences College, Nanjing Normal University, Nanjing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antimicrobial Cationic PeptidesApoptosisCell SurvivalDose-Response Relationship, DrugHEK293 CellsHumansJurkat CellsK562 CellsLeukemiaMitochondriaNecrosisReactive Oxygen SpeciesStructure-Activity RelationshipAntimicrobial Cationic PeptidesCM4 peptide, Bombyx morimyristoyl-CM4Reactive Oxygen Speciesapoptosisleukemiamulti-drug resistancemyristoyl-CM4necrosisselectivity

Identifiers

PMID31308628
PMCPMC6612960

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.