ArticleNature immunology2019
Altered differentiation is central to HIV-specific CD4
Abstract read
In one paragraph
Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
8.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Prevalence and risk factors of anemia among people living with HIV/AIDS in Southeast Asia: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- The Predictive Potential of the Baseline C-Reactive Protein Levels for the Efficiency of Immune Checkpoint Inhibitors in Cancer Patients: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2022Pooled it
- DDIT4 upregulation associates with gammadelta T Cells dysfunction in ART-suppressed people living with HIV-1.BMC infectious diseases · 2026Article
- Immune checkpoint landscape in CD4⁺ T cells stratifies HIV-infected individuals by clinical progression.Immunologic research · 2026Article
- Understanding the HIV-specific T-cell response to immune checkpoint blockade: what can we learn from cancer immunotherapy?Current opinion in HIV and AIDS · 2025Review
- Transposable elements may enhance antiviral resistance in HIV-1 elite controllers.Genome biology · 2025Article
- Immune Alterations and Viral Reservoir Atlas in SIV-Infected Chinese Rhesus Macaques.Infectious disease reports · 2025Review
- CD4, but not Cxcr6, is necessary for control of Pneumocystis murina infection.Microbes and infection · 2025Article
- HIV controllers: hope for a functional cure.Frontiers in immunology · 2025Review
- IL-27 effects on HIVFrontiers in virology (Lausanne, Switzerland) · 2025Article
- Article
- Article
- Activation-Induced Marker Assay to Identify and Isolate HCV-Specific T Cells for Single-Cell RNA-Seq Analysis.Viruses · 2024Article
- Metformin facilitates viral reservoir reactivation and their recognition by anti-HIV-1 envelope antibodies.iScience · 2024Article
- The commoneLife · 2024Article
- The commonbioRxiv : the preprint server for biology · 2024Article
- T-cell receptor sequencing reveals selected donor-reactive CD8American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Anti-Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency.The New England journal of medicine · 2024Article
- Metformin Enhances Antibody-Mediated Recognition of HIV-Infected CD4bioRxiv : the preprint server for biology · 2024Article
- Enhanced detection of antigen-specific T cells by a multiplexed AIM assay.Cell reports methods · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 6 institutions in 2 countries.
Antigoni MorouResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Elsa Brunet-RatnasinghamResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Mathieu DubéResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Roxanne CharleboisResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Eloi MercierCanadian Centre for Computational Genomics-Montréal Node, Montreal, Quebec, Canada.
Sam DarkoHuman Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.
Nathalie BrassardResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-4320-9416
Krystelle Nganou-MakamdopHuman Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.
Sahaana ArumugamHuman Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.
Gabrielle Gendron-LepageResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Lifei YangDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Julia NiesslResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0001-8852-1924
Amy E BaxterResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
James M BillingsleyYerkes National Primate Research Center and Emory University, Atlanta, GA, USA.
Premeela A RajakumarYerkes National Primate Research Center and Emory University, Atlanta, GA, USA.
François LefebvreCanadian Centre for Computational Genomics-Montréal Node, Montreal, Quebec, Canada.
R Paul JohnsonYerkes National Primate Research Center and Emory University, Atlanta, GA, USA.
Cécile TremblayResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Jean-Pierre RoutyChronic Viral Illnesses Service and Division of Hematology, McGill University Health Centre, Montreal, Quebec, Canada.
Richard T WyattCenter for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA, USA.
Andrés FinziResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Daniel C DouekHuman Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.
Daniel E KaufmannResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada. daniel.kaufmann@umontreal.ca.ORCID http://orcid.org/0000-0003-4467-136X
Centre Hospitalier de l’Université de Montréal · CAInternational AIDS Vaccine Initiative · USEmory University · USOntario Genomics · CAScripps Research Institute · USMcGill University Health Centre · CA
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MSupport Component D/Vaccine Discovery, Concept to ClinicUM1AI100663 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI AHMED, RAFI · 2012 to 2018
$131.5MNew England Primate Research Center Base GrantP51OD011103 · OD · HARVARD MEDICAL SCHOOL · PI FLIER, JEFFREY S · 2012 to 2013
$24.7MThe Genome Analysis CoreZICAI005133 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DOUEK, DANIEL CESAR · 2019 to 2025
$16.9MInflammationZIAAI005031 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DOUEK, DANIEL CESAR · 2009 to 2024
$5.9MImmunoregulatory networks and HIV pathogenesisR01HL092565 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI KAUFMANN, DANIEL E · 2007 to 2015
$3.4MNHLBI NIH HHS R01 HL092565NIAID NIH HHS UM1 AI100663NIH HHS P51 OD011103NIH HHS P51 OD011132
Abstract
Dysfunction of virus-specific CD4
Indexed as
Anti-HIV AgentsGene ExpressionGene Expression ProfilingHIV InfectionsHumansReceptors, CXCR5Th17 CellsTh1 CellsViral LoadVirus ReplicationAnti-HIV AgentsCXCR5 protein, humanReceptors, CXCR5
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.