Evidence map›Paper›PMID 31308522›Full record

ArticleNature microbiology2019

Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax.

Antonella Fioravanti, Filip Van Hauwermeiren, Sander E Van der Verren, Wim Jonckheere, Amanda Goncalves, Els Pardon, Jan Steyaert, Henri De Greve, Mohamed Lamkanfi, Han Remaut

Abstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
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  6. Collective fluctuations underlying nanobody inhibitory activity targetingbioRxiv : the preprint server for biology · 2026
    Article
  7. Review
  8. Article
  9. Cryo-EM structure and polar assembly of the PS2 S-layer ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Nanobodies in animal infectious disease control: diagnosis and therapy.Frontiers in cellular and infection microbiology · 2025
    Review
  16. Architecture of the Sap S-layer ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Review
  19. Journal of bacteriology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Antonella FioravantiStructural and Molecular Microbiology, Structural Biology Research Center, VIB, Brussels, Belgium. antonella.fioravanti@vub.be.ORCID http://orcid.org/0000-0002-4065-0839
Filip Van HauwermeirenCenter for Inflammation Research, Vlaams Instituut voor Biotechnologie, Ghent, Belgium.
Sander E Van der VerrenStructural and Molecular Microbiology, Structural Biology Research Center, VIB, Brussels, Belgium.ORCID http://orcid.org/0000-0002-8783-1194
Wim JonckheereStructural and Molecular Microbiology, Structural Biology Research Center, VIB, Brussels, Belgium.
Amanda GoncalvesVIB Bio Imaging Core, UGent-VIB, Gent, Belgium.
Els PardonStructural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.ORCID http://orcid.org/0000-0002-2466-0172
Jan SteyaertStructural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.
Henri De GreveStructural and Molecular Microbiology, Structural Biology Research Center, VIB, Brussels, Belgium.
Mohamed LamkanfiCenter for Inflammation Research, Vlaams Instituut voor Biotechnologie, Ghent, Belgium.ORCID http://orcid.org/0000-0002-4898-7663
Han RemautStructural and Molecular Microbiology, Structural Biology Research Center, VIB, Brussels, Belgium. han.remaut@vub.be.ORCID http://orcid.org/0000-0002-9775-4102
Vrije Universiteit Brussel · BEJanssen (Belgium) · BEVIB-UGent Center for Medical Biotechnology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anthrax is an ancient and deadly disease caused by the spore-forming bacterial pathogen Bacillus anthracis. At present, anthrax mostly affects wildlife and livestock, although it remains a concern for human public health-primarily for people who handle contaminated animal products and as a bioterrorism threat due to the high resilience of spores, a high fatality rate of cases and the lack of a civilian vaccination programme

Indexed as

AnimalsAnthraxBacillus anthracisDisease Models, AnimalInjections, SubcutaneousMembrane GlycoproteinsMiceMicrobial ViabilityModels, MolecularProtein Conformation, beta-StrandProtein MultimerizationSingle-Domain AntibodiesMembrane GlycoproteinsSingle-Domain AntibodiesS-layer proteins

Identifiers

PMID31308522
OpenAlexW2957845089

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.