Evidence map›Paper›PMID 31308506›Full record

ArticleNature medicine2019

Metabolic perturbations and cellular stress underpin susceptibility to symptomatic live-attenuated yellow fever infection.

Kuan Rong Chan, Esther Shuyi Gan, Candice Yuen Yue Chan, Cui Liang, John Zhong Heng Low, Summer Li-Xin Zhang, Eugenia Ziying Ong, Ashwin Bhatta, Limin Wijaya, Yie Hou Lee and 2 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07527247 (Using AS01 Adjuvant to Improve Immune Response in Older Adults Through Trained Immunity), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07527247 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Using AS01 Adjuvant to Improve Immune Response in Older Adults Through Trained Immunity

TypeinterventionalSponsorSingapore General HospitalRan2025 to 2029Enrolled40ConditionsImmune System Responses and Trained Immunity After AS01 Administration, Healthy AdultArmsAS01 adjuvant (0.5 mL intramuscular), YF17D (Stamaril, Sanofi-Pasteur), Placebo (NaCl 09%, 0.5mL)
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Kuan Rong ChanEmerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore. kuanrong.chan@duke-nus.edu.sg.ORCID http://orcid.org/0000-0002-2427-671X
Esther Shuyi GanEmerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore.
Candice Yuen Yue ChanEmerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore.
Cui LiangSingapore-MIT Alliance in Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group, Singapore, Singapore.
John Zhong Heng LowDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Summer Li-Xin ZhangEmerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore.
Eugenia Ziying OngViral Research & Experimental Medicine Center, SingHealth/Duke-NUS (ViREMiCS), Singapore, Singapore.
Ashwin BhattaEmerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore.
Limin WijayaDepartment of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.
Yie Hou LeeSingapore-MIT Alliance in Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group, Singapore, Singapore.ORCID http://orcid.org/0000-0003-2723-2023
Jenny Guek-Hong LowEmerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore. jenny.low@singhealth.com.sg.ORCID http://orcid.org/0000-0002-3876-2209
Eng Eong OoiEmerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore. engeong.ooi@duke-nus.edu.sg.ORCID http://orcid.org/0000-0002-0520-1544
SingHealth · SGDuke-NUS Medical School · SGSingapore General Hospital · SGKK Women's and Children's Hospital · SGSingapore-MIT Alliance for Research and Technology · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flaviviral infections result in a wide spectrum of clinical outcomes, ranging from asymptomatic infection to severe disease. Although the correlates of severe disease have been explored

Indexed as

Endoplasmic Reticulum StressAdultCitric Acid CycleDisease SusceptibilityHumansMiddle AgedReactive Oxygen SpeciesVaccines, AttenuatedYellow FeverYellow Fever VaccineReactive Oxygen SpeciesVaccines, AttenuatedYellow Fever Vaccine

Identifiers

PMID31308506
OpenAlexW2962537471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.