ArticleNature nanotechnology2019
Localized detection of ions and biomolecules with a force-controlled scanning nanopore microscope.
Article in Nature nanotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 62 citations in OpenAlex.
- Review
- Noninvasive methods to monitor dynamic single-cell events.Trends in cell biology · 2026Review
- Stress-induced ripping enables fabrication of nanopores with dimensions smaller than the resolution limit of the employed lithography.Science advances · 2026Article
- Label-free robotic mitochondrial biopsy.Science advances · 2025Article
- Bifunctional nanoprobe for simultaneous detection of intracellular reactive oxygen species and temperature in single cells.Microsystems & nanoengineering · 2024Article
- Dissecting cell membrane tension dynamics and its effect on Piezo1-mediated cellular mechanosensitivity using force-controlled nanopipettes.Nature methods · 2024Article
- Single molecule delivery into living cells.Nature communications · 2024Article
- Aptamer-Functionalized Interface Nanopores Enable Amino Acid-Specific Peptide Detection.ACS nano · 2024Article
- Solid-State Nanopores for Biomolecular Analysis and Detection.Advances in biochemical engineering/biotechnology · 2024Review
- Controllable Shrinking Fabrication of Solid-State Nanopores.Micromachines · 2022Review
- Population distributions of single-cell adhesion parameters during the cell cycle from high-throughput robotic fluidic force microscopy.Scientific reports · 2022Article
- Robotic Intracellular Electrochemical Sensing for Adherent Cells.Cyborg and bionic systems (Washington, D.C.) · 2022Article
- Scanning Ion Conductance Microscopy.Chemical reviews · 2021Review
- The emerging landscape of single-molecule protein sequencing technologies.Nature methods · 2021Review
- The Most Recent Advances in the Application of Nano-Structures/Nano-Materials for Single-Cell Sampling.Frontiers in chemistry · 2020Review
- A new tool for cell signalling research.Nature nanotechnology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins, nucleic acids and ions secreted from single cells are the key signalling factors that determine the interaction of cells with their environment and the neighbouring cells. It is possible to study individual ion channels by pipette clamping, but it is difficult to dynamically monitor the activity of ion channels and transporters across the cellular membrane. Here we show that a solid-state nanopore integrated in an atomic force microscope can be used for the stochastic sensing of secreted molecules and the activity of ion channels in arbitrary locations both inside and outside a cell. The translocation of biomolecules and ions through the nanopore is observed in real time in live cells. The versatile nature of this approach allows us to detect specific biomolecules under controlled mechanical confinement and to monitor the ion-channel activities of single cells. Moreover, the nanopore microscope was used to image the surface of the nuclear membrane via high-resolution scanning ion conductance measurements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.