ArticleScientific reports2019
One step conjugation of some chemotherapeutic drugs to the biologically produced gold nanoparticles and assessment of their anticancer effects.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 80 citations in OpenAlex.
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- Bioproduced Nanoparticles Deliver Multiple Cargoes via Targeted Tumor Therapy In Vivo.ACS omega · 2024Article
- Conjugation of microbial-derived gold nanoparticles to different types of nucleic acids: evaluation of transfection efficiency.Scientific reports · 2023Article
- One Pot Synthesis, Biological Efficacy of AuNPs and Au-Amoxicillin Conjugates Functionalized with Crude Flavonoids Extract ofMolecules (Basel, Switzerland) · 2023Article
- Fate of the capping agent of biologically produced gold nanoparticles and adsorption of enzymes onto their surface.Scientific reports · 2023Article
- Green Synthesis of Endolichenic Fungi Functionalized Silver Nanoparticles: The Role in Antimicrobial, Anti-Cancer, and Mosquitocidal Activities.International journal of molecular sciences · 2022Article
- Investigation of Protein Corona Formed around Biologically Produced Gold Nanoparticles.Materials (Basel, Switzerland) · 2022Article
- Conjugation of VEGFR1/R2-targeting peptide with gold nanoparticles to enhance antiangiogenic and antitumoral activity.Journal of nanobiotechnology · 2022Article
- Mycofabrication of AgONPs derived from Aspergillus terreus FC36AY1 and its potent antimicrobial, antioxidant, and anti-angiogenesis activities.Molecular biology reports · 2021Article
- Bright Side ofJournal of fungi (Basel, Switzerland) · 2021Review
- Biogenic Silver Nanoparticles: What We Know and What Do We Need to Know?Nanomaterials (Basel, Switzerland) · 2021Review
- Comparison of the possible histopathological changes of the rat neonatal cerebellum induced by toxic and nontoxic doses of biological silver nanoparticles with chemical silver nanoparticles.Brain and behavior · 2021Article
- Surface functionalisation of poly-APO-b-polyol ester cross-linked copolymers as core-shell nanoparticles for targeted breast cancer therapy.Scientific reports · 2020Article
- Gold nanoparticle‑mediated delivery of paclitaxel and nucleic acids for cancer therapy (Review).Molecular medicine reports · 2020Review
- Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Promising opportunities and potential risk of nanoparticle on the society.IET nanobiotechnology · 2020Review
- Gold Nanocomplex Strongly Modulates the PI3K/Akt Pathway and Other Pathways in MCF-7 Breast Cancer Cell Line.International journal of molecular sciences · 2020Article
- Histopathological study of the maternal exposure to the biologically produced silver nanoparticles on different organs of the offspring.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Synthesis of Silver Nanoparticles Mediated by Fungi: A Review.Frontiers in bioengineering and biotechnology · 2019Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent research tried to analyze the conjugation of some chemotherapeutic drugs to the biologically produced gold nanoparticles (GNPs) in one step, without the use of any additional linkers. GNPs was produced using Fusarium oxysporum and their presence was confirmed using spectrophotometer, transmission electron microscope (TEM), X-ray diffraction (XRD) and fourier transform infrared (FTIR) analyses. In order to carry out the conjugation study, capecitabine, tamoxifen, and paclitaxel were added dropwise to the GNPs solution under stirring condition and spectrophotometer, dynamic light scattering (DLS) and FTIR analyses were performed to prove the successful conjugation. Finally, AGS and MCF7 cell lines were used for methyl thiazol tetrazolium (MTT) assay to determine the toxicity of each drug and its conjugated form. Results showed that the spherical and hexagonal GNPs with maximum absorbance peak around 524 nm and average sizes less than 20 nm were produced. FTIR analysis clarified the presence of proteins on the surfaces of the GNPs. After the conjugation process although the FTIR analysis demonstrated that all the drugs were successfully conjugated to GNPs, MTT assay revealed that unlike the paclitaxel conjugated GNPs, capecitabine and tamoxifen conjugates displayed no toxic effects due to their deactivation and low half-lives. Moreover the average size and polydispersity index (PDI) of the GNPs after conjugation with all the three tested drugs increased. In conclusion different types of drugs could conjugate to the GNPs but it is important to employ high stable forms of the drugs in the conjugation procedure.
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