ArticleScientific reports2019
Dynamics of cheater invasion in a cooperating population of Pseudomonas aeruginosa.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Inactivation of MexT inJournal of bacteriology · 2026Article
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- Pathogenicity and virulence ofVirulence · 2025Review
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- Inactivation of MexT inbioRxiv : the preprint server for biology · 2025Article
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- From single cells to communities: Mathematical perspectives on bacterial quorum sensing.Computational and structural biotechnology journal · 2025Review
- A balancing act: investigations on the impact of altered signal sensitivity in bacterial quorum sensing.Journal of bacteriology · 2023Article
- T2SS-peptidase XcpA associated with LasR evolutional phenotypic variations provides a fitness advantage toFrontiers in microbiology · 2023Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
Pseudomonas aeruginosa quorum sensing (QS) regulates expression of dozens of genes in a cell density-dependent manner. Many QS-regulated genes code for production of extracellular factors, "public goods" that can benefit the entire population. This cooperation encourages individuals to cheat by using but not producing public goods. QS also controls expression of a limited number of genes encoding "private" cellular enzymes like Nuh, an enzyme involved in adenosine catabolism. Growth of P. aeruginosa on casein requires QS-regulated production of an extracellular protease and is an example of cooperative behavior. When P. aeruginosa is transferred daily on casein, QS mutants emerge. These cheaters have mutations in lasR, which encodes the primary QS transcription factor. When growth is on casein and adenosine, cheater emergence is constrained. Here, we report the dynamics of LasR mutant invasion during growth on casein or casein plus adenosine. We show that LasR mutants have the greatest advantage during early to mid-logarithmic growth on casein. Addition of adenosine to casein medium constrains cheaters throughout growth. Our data support the view that co-regulation of the public protease and the private nucleosidase by QS stabilizes cooperation, and the data are not consistent with other proposed alternate hypotheses.
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Registered trials
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