ArticleScientific reports2019
Environmentally-Controlled Near Infrared Spectroscopic Imaging of Bone Water.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Bone hydration: How we can evaluate it, what can it tell us, and is it an effective therapeutic target?Bone reports · 2022Article
- Applications of Vibrational Spectroscopy for Analysis of Connective Tissues.Molecules (Basel, Switzerland) · 2021Review
- Characterization of connective tissues using near-infrared spectroscopy and imaging.Nature protocols · 2021Article
- Near infrared spectroscopic assessment of loosely and tightly bound cortical bone water.The Analyst · 2020Article
- Approaches forTissue engineering. Part C, Methods · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
We have designed an environmentally-controlled chamber for near infrared spectroscopic imaging (NIRSI) to monitor changes in cortical bone water content, an emerging biomarker related to bone quality assessment. The chamber is required to ensure repeatable spectroscopic measurements of tissues without the influence of atmospheric moisture. A calibration curve to predict gravimetric water content from human cadaveric cortical bone was created using NIRSI data obtained at six different lyophilization time points. Partial least squares (PLS) models successfully predicted bone water content that ranged from 0-10% (R = 0.96, p < 0.05, root mean square error of prediction (RMSEP) = 7.39%), as well as in the physiologic range of 4-10% of wet tissue weight (R = 0.87, p < 0.05, RMSEP = 14.5%). Similar results were obtained with univariate and bivariate regression models for prediction of water in the 0-10% range. Further, we identified two new NIR bone absorbances, at 6560 cm
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