ArticleExperimental animals2020
Establishment of a new formula for QT interval correction using a large colony of cynomolgus monkeys.
Article in Experimental animals, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Double-Chambered Right Ventricle and Intraventricular Thrombosis Mimicking Double-Chambered Right Ventricle in Cynomolgus Monkeys (Macaca fascicularis).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Validation of a Demography-Based Adaptive QT Correction Formula Using Pediatric and Adult Datasets Acquired From Humans and Guinea Pigs.Circulation. Arrhythmia and electrophysiology · 2025Article
- The "One-Step" approach for QT analysis increases the sensitivity of nonclinical QTc analysis.Clinical and translational science · 2023Article
- Long-term QT prolongation in monkeys after doxorubicin administration at doses similar to breast cancer therapy.Frontiers in cardiovascular medicine · 2023Article
- A diastolic dysfunction model in non-human primates with transverse aortic constriction.Experimental animals · 2021Article
- Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus monkeys (Macaca fascicularis).The Journal of veterinary medical science · 2021Article
- Echocardiographic evaluation of cardiac function in cynomolgus monkeys over a wide age range.Experimental animals · 2020Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The demand for monkeys for medical research is increasing, because their ionic mechanism of repolarization is similar to that of humans. The QT interval is the distance between the Q wave and T wave, but this interval is affected by heart rate. Therefore, QT correction methods are commonly used in clinical settings. However, an accurate correction formula for the QT interval in cynomolgus monkeys has not been reported. We assessed snapshot electrocardiograms (ECGs) of 353 ketamine-immobilized monkeys, including aged animals, and contrived a new formula for the corrected QT interval (QTc) as a marker of QT interval prolongation in cynomolgus monkeys. Values for QTc were calculated using the formula [QTc] = [QT] / [RR]
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