Evidence map›Paper›PMID 31308145›Full record

ReviewCold Spring Harbor perspectives in biology2020

Identifying New Substrates and Functions for an Old Enzyme: Calcineurin.

Jagoree Roy, Martha S Cyert

Open access · hybridAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Calcineurin controls the cytokinesis machinery during thermal stress inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. The role of mechanosignaling in the control of myocardial mass.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jagoree RoyDepartment of Biology, Stanford University, Stanford, California 94305-5020.
Martha S CyertDepartment of Biology, Stanford University, Stanford, California 94305-5020.
Stanford University · US

Funding

Systematic elucidation of calcineurin phosphatase signaling in humansR35GM136243 · NIGMS · STANFORD UNIVERSITY · PI Martha S. Cyert · 2020 to 2026
$3.9M
Identifying The Human Calcineurin Signaling NetworkR01GM119336 · NIGMS · STANFORD UNIVERSITY · PI CYERT, MARTHA S. · 2016 to 2019
$2.0M
NIGMS NIH HHS R01 GM119336NIGMS NIH HHS R35 GM136243
6 · The paper itself

Abstract

Biological processes are dynamically regulated by signaling networks composed of protein kinases and phosphatases. Calcineurin, or PP3, is a conserved phosphoserine/phosphothreonine-specific protein phosphatase and member of the PPP family of phosphatases. Calcineurin is unique, however, in its activation by Ca

Indexed as

Gene Expression RegulationAmino Acid MotifsAnimalsCalcineurinCalcineurin InhibitorsCalciumComputer SimulationCyclosporineHumansHypertensionImmune SystemImmunosuppression TherapyImmunosuppressive AgentsIsoenzymesNFATC Transcription FactorsNuclear ProteinsCalcineurinCalcineurin InhibitorsCalciumCyclosporineImmunosuppressive AgentsIsoenzymesNFATC Transcription FactorsNuclear ProteinsPhosphoric Monoester HydrolasesProtein IsoformsTacrolimus

Identifiers

PMID31308145
PMCPMC7050593
OpenAlexW2956424523

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.