Evidence map›Paper›PMID 31308130›Full record

ArticleMolecular and cellular biology2019

Calcineurin Broadly Regulates the Initiation of Skeletal Muscle-Specific Gene Expression by Binding Target Promoters and Facilitating the Interaction of the SWI/SNF Chromatin Remodeling Enzyme.

Hanna Witwicka, Jumpei Nogami, Sabriya A Syed, Kazumitsu Maehara, Teresita Padilla-Benavides, Yasuyuki Ohkawa, Anthony N Imbalzano

Open access · hybridAbstract read
In one paragraph

Article in Molecular and cellular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

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  6. Muscle-specific pyruvate kinase isoforms, PKM1 and PKM2, regulate mammalian SWI/SNF proteins and histone 3 phosphorylation during myoblast differentiation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
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  15. Review
  16. Article
  17. The Role of BRG1 in Antioxidant and Redox Signaling.Oxidative medicine and cellular longevity · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Hanna WitwickaDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jumpei NogamiDivision of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Higashiku, Fukuoka, Japan.
Sabriya A SyedDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Kazumitsu MaeharaDivision of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Higashiku, Fukuoka, Japan.
Teresita Padilla-BenavidesDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Yasuyuki OhkawaDivision of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Higashiku, Fukuoka, Japan.
Anthony N ImbalzanoDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA Anthony.Imbalzano@umassmed.edu.
University of Massachusetts Chan Medical School · USKyushu University · JP

Funding

TRANSCRIPTION FACTOR FUNCTION IN CHROMATINR01GM056244 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI IMBALZANO, ANTHONY N · 1997 to 2019
$6.7M
NIGMS NIH HHS R01 GM056244
6 · The paper itself

Abstract

Calcineurin (Cn) is a calcium-activated serine/threonine protein phosphatase that is broadly implicated in diverse cellular processes, including the regulation of gene expression. During skeletal muscle differentiation, Cn activates the

Indexed as

Gene Regulatory NetworksAnimalsCalcineurinCell DifferentiationCell LineChromatin Assembly and DisassemblyChromosomal Proteins, Non-HistoneDNA HelicasesGene Expression ProfilingGene Expression RegulationMiceMyoblastsMyoD ProteinNuclear ProteinsPromoter Regions, GeneticTacrolimusCalcineurinChromosomal Proteins, Non-HistoneDNA HelicasesMyoD1 myogenic differentiation proteinMyoD ProteinNuclear ProteinsSmarca4 protein, mouseSWI-SNF-B chromatin-remodeling complexTacrolimusTranscription FactorsBrg1calcineurinchromatin remodelingdifferentiationgene regulationmyogenesisSWI/SNF

Identifiers

PMID31308130
PMCPMC6751634
OpenAlexW2957070098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.