Evidence map›Paper›PMID 31308088›Full record

ArticleInfection and immunity2019

A Cross-Reactive Protein Vaccine Combined with PCV-13 Prevents Streptococcus pneumoniae- and Haemophilus influenzae-Mediated Acute Otitis Media.

Hannah M Rowe, Beth Mann, Amy Iverson, Aaron Poole, Elaine Tuomanen, Jason W Rosch

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Panel 1: Biotechnology, biomedical engineering and new models of otitis media.International journal of pediatric otorhinolaryngology · 2020
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hannah M RoweDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Beth MannDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Amy IversonDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Aaron PooleDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Elaine TuomanenDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jason W RoschDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA Jason.Rosch@stjude.org.
St. Jude Children's Research Hospital · US

Funding

Predicting the emergence of antibiotic resistance through multi-omics approaches and Immune System-surveillanU01AI124302 · NIAID · BOSTON COLLEGE · PI BENTO, JOSE, COOPER, VAUGHN · 2016 to 2020
$10.2M
Bioactivities of pneumococcal cell wall in neuropathogenesisR01AI128756 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Elaine I Tuomanen · 2017 to 2026
$4.5M
Pneumococcal pathogenesis in sickle cell diseaseR01AI110618 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ROSCH, JASON W. · 2015 to 2019
$2.2M
NIAID NIH HHS R01 AI110618NIAID NIH HHS R01 AI128756NIAID NIH HHS U01 AI124302
6 · The paper itself

Abstract

Acute otitis media is one of the most common childhood infections worldwide. Currently licensed vaccines against the common otopathogen

Indexed as

Acute DiseaseAnimalsAntibodies, BacterialBacterial ProteinsCross ProtectionCross ReactionsFemaleGene ExpressionHaemophilus InfectionsHaemophilus influenzaeHumansImmunogenicity, VaccineMiceMice, Inbred BALB COtitis MediaPneumococcal VaccinesAntibodies, BacterialBacterial ProteinsCbpA protein, bacteriaplY protein, Streptococcus pneumoniaePneumococcal VaccinesRecombinant Fusion ProteinsStreptolysinsToxoidsVaccines, SyntheticHaemophilus influenzae, Streptococcus pneumoniaeotitis mediavaccines

Identifiers

PMID31308088
PMCPMC6759292
OpenAlexW2959491363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.