Evidence map›Paper›PMID 31308085›Full record

ArticleInfection and immunity2019

Antibody-Dependent, Gamma Interferon-Independent Sterilizing Immunity Induced by a Subunit Malaria Vaccine.

Bhavna Chawla, Babita Mahajan, Miranda Oakley, Victoria F Majam, Arnel Belmonte, Martha Sedegah, Richard L Shimp, David C Kaslow, Sanjai Kumar

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. A multivalentBioengineering & translational medicine · 2023
    Article
  3. Review
  4. Article
  5. Infection and immunity · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Bhavna ChawlaDivision of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Babita MahajanDivision of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Miranda OakleyDivision of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Victoria F MajamDivision of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Arnel BelmonteNaval Medical Research Center, Silver Spring, Maryland, USA.
Martha SedegahNaval Medical Research Center, Silver Spring, Maryland, USA.
Richard L ShimpLaboratory of Malaria Immunology and Vaccinology, NIAID, NIH, Rockville, Maryland, USA.
David C KaslowPATH Essential Medicines, Seattle, Washington, USA.
Sanjai KumarDivision of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA Sanjai.Kumar@fda.hhs.gov.
Center for Biologics Evaluation and Research · USNaval Medical Research Command · USUnited States Food and Drug Administration · USNational Institute of Allergy and Infectious Diseases · USProgram for Appropriate Technology in Health · US

Funding

Pre-erythrocytic malaria vaccines: Discovery and Clinical DevelopmentZIAAI001135 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DUFFY, PATRICK · 2010 to 2025
$6.4M
6 · The paper itself

Abstract

The development of effective malaria vaccines is hampered by incomplete understanding of the immunological correlates of protective immunity. Recently, the moderate clinical efficacy of the

Indexed as

Adjuvants, ImmunologicAnimalsAntibodies, ProtozoanCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleImmunizationImmunogenicity, VaccineImmunoglobulin GInterferon-gammaInterleukin-2Interleukin-4MalariaMalaria VaccinesMannitolMiceAdjuvants, ImmunologicAntibodies, Protozoancircumsporozoite protein, ProtozoanCpG ODN 1826Immunoglobulin GInterferon-gammaInterleukin-2Interleukin-4Malaria VaccinesMannitolmontanide ISA 51Oleic AcidsOligodeoxyribonucleotidesProtozoan ProteinsTumor Necrosis Factor-alphaVaccines, Subunitantibodiesmalariaprotectionvaccine

Identifiers

PMID31308085
PMCPMC6759290
OpenAlexW2974773766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.