Evidence map›Paper›PMID 31308080›Full record

ArticleInfection and immunity2019

Staphylococcus aureus Lipoic Acid Synthesis Limits Macrophage Reactive Oxygen and Nitrogen Species Production To Promote Survival during Infection.

James P Grayczyk, Francis Alonzo

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. iScience · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Structure and Nitrite Reductase Activity of the Di-iron Protein ScdA inJournal of the American Chemical Society · 2025
    Article
  6. Article
  7. Strategies for Survival ofInternational journal of molecular sciences · 2025
    Review
  8. Article
  9. Intracellular Habitation ofBiomedicines · 2022
    Review
  10. Exploring the Role ofToxins · 2022
    Review
  11. Review
  12. Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Emerging Evasion Mechanisms of Macrophage Defenses by Pathogenic Bacteria.Frontiers in cellular and infection microbiology · 2020
    Review
  18. The Role of Macrophages inFrontiers in immunology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

James P GrayczykDepartment of Microbiology and Immunology, Loyola University Chicago-Stritch School of Medicine, Maywood, Illinois, USA.
Francis AlonzoDepartment of Microbiology and Immunology, Loyola University Chicago-Stritch School of Medicine, Maywood, Illinois, USA falonzo@luc.edu.
Loyola University Chicago · US

Funding

Staphylococcus aureus Survival During Nutrient Restriction and Suppression of Host Immunity.R01AI120994 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Francis Alonzo · 2016 to 2026
$4.6M
American Heart Association-American Stroke Association 17PRE33660173NIAID NIH HHS R01 AI120994
6 · The paper itself

Abstract

Macrophages are critical mediators of innate immunity and must be overcome for bacterial pathogens to cause disease. The Gram-positive bacterium

Indexed as

Gene Expression Regulation, BacterialAnimalsBacterial ProteinsFemaleHost-Pathogen InteractionsMacrophage ActivationMacrophages, PeritonealMaleMiceMicrobial ViabilityMutationNADPH OxidasesNitric Oxide Synthase Type IIReactive Nitrogen SpeciesReactive Oxygen SpeciesStaphylococcal InfectionsBacterial ProteinsLipA protein, BacteriaNADPH OxidasesNitric Oxide Synthase Type IINos2 protein, mouseReactive Nitrogen SpeciesReactive Oxygen SpeciesThioctic Acidlipoic acidmacrophagesmetabolismreactive nitrogen speciesreactive oxygen speciesStaphylococcus aureusvirulence

Identifiers

PMID31308080
PMCPMC6759302
OpenAlexW2957325079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.