Evidence map›Paper›PMID 31308006›Full record

ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2019

Maternal prepregnancy surgery and risk of neonatal abstinence syndrome in future newborns: a longitudinal cohort study.

Nathalie Auger, Nancy Low, François M Carrier, Aimina Ayoub, Thuy Mai Luu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Nathalie AugerUniversity of Montreal Hospital Research Centre (Auger, Carrier, Ayoub), School of Public Health; Institut national de santé publique du Québec (Auger, Ayoub); Department of Psychiatry (Low), McGill University; Departments of Anesthesiology and Medicine (Carrier), Critical Care Division, University of Montreal Hospital; Department of Pediatrics (Luu), Sainte-Justine Hospital Research Centre, University of Montreal, Montréal, Que. nathalie.auger@inspq.qc.ca.
Nancy LowUniversity of Montreal Hospital Research Centre (Auger, Carrier, Ayoub), School of Public Health; Institut national de santé publique du Québec (Auger, Ayoub); Department of Psychiatry (Low), McGill University; Departments of Anesthesiology and Medicine (Carrier), Critical Care Division, University of Montreal Hospital; Department of Pediatrics (Luu), Sainte-Justine Hospital Research Centre, University of Montreal, Montréal, Que.
François M CarrierUniversity of Montreal Hospital Research Centre (Auger, Carrier, Ayoub), School of Public Health; Institut national de santé publique du Québec (Auger, Ayoub); Department of Psychiatry (Low), McGill University; Departments of Anesthesiology and Medicine (Carrier), Critical Care Division, University of Montreal Hospital; Department of Pediatrics (Luu), Sainte-Justine Hospital Research Centre, University of Montreal, Montréal, Que.
Aimina AyoubUniversity of Montreal Hospital Research Centre (Auger, Carrier, Ayoub), School of Public Health; Institut national de santé publique du Québec (Auger, Ayoub); Department of Psychiatry (Low), McGill University; Departments of Anesthesiology and Medicine (Carrier), Critical Care Division, University of Montreal Hospital; Department of Pediatrics (Luu), Sainte-Justine Hospital Research Centre, University of Montreal, Montréal, Que.
Thuy Mai LuuUniversity of Montreal Hospital Research Centre (Auger, Carrier, Ayoub), School of Public Health; Institut national de santé publique du Québec (Auger, Ayoub); Department of Psychiatry (Low), McGill University; Departments of Anesthesiology and Medicine (Carrier), Critical Care Division, University of Montreal Hospital; Department of Pediatrics (Luu), Sainte-Justine Hospital Research Centre, University of Montreal, Montréal, Que.
Université de Montréal · CACarrier (United States) · USMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeonatal abstinence syndrome is increasingly prevalent, and may be related to opioid use disorders caused by postoperative prescriptions for pain control. We assessed the association of maternal prepregnancy surgery with risk of neonatal abstinence syndrome from opioid use disorders in future pregnancies.

methodsWe conducted a longitudinal retrospective cohort study of 2 182 365 deliveries in Quebec, Canada, between 1989 and 2016. The main exposure was maternal prepregnancy surgery. The main outcome measure was neonatal abstinence syndrome in offspring. We adjusted associations for maternal comorbidity and pregnancy characteristics using log-binomial regression models.

resultsThe prevalence of neonatal abstinence syndrome in the cohort was 10.7 per 10 000 births. Compared with no surgery, prepregnancy surgery was associated with a risk ratio (RR) of neonatal abstinence syndrome of 1.63 (95% confidence interval [CI] 1.49-1.78). Risk was greater for 3 or more prepregnancy surgeries (RR 2.34, 95% CI 2.07-2.63) and age < 15 years at first surgery (1 surgery: RR 2.08, 95% CI 1.71-2.54; 2 or more surgeries: RR 2.79, 95% CI 2.32-3.37). Nearly all surgical specialties increased the risk of neonatal abstinence syndrome, but associations were strongest for cardiothoracic surgery (RR 4.45, 95% CI 2.87-6.91), neurosurgery (RR 3.00, 95% CI 1.56-5.77) and urologic surgery (RR 3.03, 95% CI 2.16-4.26).

interpretationPrepregnancy surgery is associated with the risk of neonatal abstinence syndrome in future pregnancies. Prescription opioids for postsurgical pain may result in opioid use disorders during future pregnancies, inadvertently increasing the risk of neonatal abstinence syndrome in offspring.

Indexed as

AdultAnalgesics, OpioidFemaleHumansInfant, NewbornLongitudinal StudiesNeonatal Abstinence SyndromeOpioid-Related DisordersPostoperative ComplicationsPregnancyPrenatal Exposure Delayed EffectsQuebecAnalgesics, Opioid

Identifiers

PMID31308006
PMCPMC6629530
OpenAlexW2961680972

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.