Evidence map›Paper›PMID 31307985›Full record

Trial reportAntimicrobial agents and chemotherapy2019

Impact of Antibiotic Gut Exposure on the Temporal Changes in Microbiome Diversity.

Charles Burdet, Thu Thuy Nguyen, Xavier Duval, Stéphanie Ferreira, Antoine Andremont, Jérémie Guedj, France Mentré, DAV132-CL-1002 Study Group

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 57 citations in OpenAlex.

  1. Effects of Tanreqing injection on the gut microbiota in healthy volunteers.Frontiers in cellular and infection microbiology · 2024
    Trial
  2. Trial
  3. Article
  4. Review
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Antibiotic-perturbed microbiota and the role of probiotics.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. The Microbiome and Infectious Diseases.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. MiniBioReactor Array (MBRA)JAC-antimicrobial resistance · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Charles BurdetIAME, INSERM, Université de Paris, Paris, France charles.burdet@inserm.fr.
Thu Thuy NguyenIAME, INSERM, Université de Paris, Paris, France.
Xavier DuvalIAME, INSERM, Université de Paris, Paris, France.
Stéphanie FerreiraGenoscreen, Lille, France.
Antoine AndremontIAME, INSERM, Université de Paris, Paris, France.
Jérémie GuedjIAME, INSERM, Université de Paris, Paris, France.
France MentréIAME, INSERM, Université de Paris, Paris, France.
DAV132-CL-1002 Study Group
Inserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the global deleterious impact of antibiotics on the intestinal microbiota is well known, temporal changes in microbial diversity during and after an antibiotic treatment are still poorly characterized. We used plasma and fecal samples collected frequently during treatment and up to one month after from 22 healthy volunteers assigned to a 5-day treatment by moxifloxacin (

Indexed as

AdultAnti-Bacterial AgentsBacteriaFecesFemaleGastrointestinal MicrobiomeHealthy VolunteersHumansMaleMicrobiotaMiddle AgedMoxifloxacinRNA, Ribosomal, 16SSequence Analysis, DNAYoung AdultAnti-Bacterial AgentsMoxifloxacinRNA, Ribosomal, 16Sdiversitydysbiosisintestinal microbiomemetagenomicsmoxifloxacinnonlinear mixed-effect modelling

Identifiers

PMID31307985
PMCPMC6761552
OpenAlexW2960706418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.