Evidence map›Paper›PMID 31307977›Full record

ArticleAntimicrobial agents and chemotherapy2019

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay.

Filip Zmuda, Lalitha Sastry, Sharon M Shepherd, Deuan Jones, Alison Scott, Peter D Craggs, Alvaro Cortes, David W Gray, Leah S Torrie, Manu De Rycker

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Repurposing of rabeprazole as an anti-Journal of enzyme inhibition and medicinal chemistry · 2023
    Article
  4. Article
  5. Covalent Inhibition of thePharmaceuticals (Basel, Switzerland) · 2022
    Article
  6. Article
  7. Article
  8. Review
  9. Challenges in Chagas Disease Drug Development.Molecules (Basel, Switzerland) · 2020
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Filip ZmudaDrug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Lalitha SastryDrug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Sharon M ShepherdProtein Production Team, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Deuan JonesDrug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Alison ScottProtein Production Team, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Peter D CraggsScreening Compound Profiling and Mechanistic Biology, Platform Technology and Science, GlaxoSmithKline, Stevenage, United Kingdom.
Alvaro CortesScreening Compound Profiling and Mechanistic Biology, Platform Technology and Science, GlaxoSmithKline, Stevenage, United Kingdom.
David W GrayDrug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom d.w.gray@dundee.ac.uk m.derycker@dundee.ac.uk.
Leah S TorrieDrug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Manu De RyckerDrug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom d.w.gray@dundee.ac.uk m.derycker@dundee.ac.uk.ORCID 0000-0002-3171-3519

Funding

Wellcome Trust 203134/Z/16/ZWellcome Trust 204672/Z/16/Z
6 · The paper itself

Abstract

Chagas' disease, caused by the protozoan parasite

Indexed as

Cell-Free SystemHigh-Throughput Screening AssaysLuminescenceProteasome Endopeptidase ComplexProteasome InhibitorsProtozoan ProteinsReproducibility of ResultsTrypanocidal AgentsTrypanosoma cruziProteasome Endopeptidase ComplexProteasome InhibitorsProtozoan ProteinsTrypanocidal Agentsassay developmentChagas’ diseasedrug discoverydrug screeningpharmacologyproteasomeTrypanosoma cruzi

Identifiers

PMID31307977
PMCPMC6709497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.