ArticleCritical care (London, England)2019
Recovery from acute kidney injury as a potent predictor of survival and good neurological outcome at discharge after out-of-hospital cardiac arrest.
Article in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Preclinical evidence for supra-clinical acute kidney injury: current biomarkers are not enough.Intensive care medicine experimental · 2026Article
- Association between blood pressure response index and in-hospital outcomes in cardiac arrest patients: A retrospective study.Medicine · 2026Article
- Dual-phase CT radiomics for acute kidney injury prediction after out-of-hospital cardiac arrest.Frontiers in radiology · 2026Article
- Assessing renal recovery after acute kidney injury in elderly patients: a retrospective cohort study.Renal failure · 2025Article
- Proteomics identify pathogenesis and novel biomarkers for monitoring and early prognostication of brain injury after cardiac arrest: a randomized animal study.Resuscitation plus · 2025Article
- Renal function and clinical outcomes in survivors of out-of-hospital cardiac arrest.Resuscitation plus · 2025Article
- Temporal trends in organ donation among cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation.Resuscitation · 2024Article
- Extracerebral multiple organ dysfunction and interactions with brain injury after cardiac arrest.Resuscitation plus · 2024Review
- Factors predicting mortality in the cardiac ICU during the early phase of targeted temperature management in the treatment of post-cardiac arrest syndrome - The RAPID score.Resuscitation plus · 2024Article
- Acute kidney injury after out-of-hospital cardiac arrest.Critical care (London, England) · 2024Article
- A Comparison of Prognostic Factors in a Large Cohort of In-Hospital and Out-of-Hospital Cardiac Arrest Patients.Life (Basel, Switzerland) · 2024Article
- Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest.Journal of molecular and cellular cardiology plus · 2023Article
- Risperidone Administration Attenuates Renal Ischemia and Reperfusion Injury following Cardiac Arrest by Antiinflammatory Effects in Rats.Veterinary sciences · 2023Article
- Prognostic significance of the blood urea nitrogen to creatinine ratio in in-hospital cardiac arrest after targeted temperature management.Journal of the Chinese Medical Association : JCMA · 2022Article
- Metformin protects against cardiac and renal damage in diabetic cardiac arrest patients.Resuscitation · 2022Article
- Acute kidney injury after in-hospital cardiac arrest in a predominant internal medicine and cardiology patient population: incidence, risk factors, and impact on survival.Renal failure · 2021Article
- Recovery from Acute Kidney Injury Is a Potent Predictor of Survival and Good Neurological Outcome at Discharge After Out-of-hospital Cardiac Arrest: Fact Or Fiction.Journal of translational internal medicine · 2021Article
- Observational
- Renal replacement therapy is independently associated with a lower risk of death in patients with severe acute kidney injury treated with targeted temperature management after out-of-hospital cardiac arrest.Critical care (London, England) · 2020Observational
- Management of post-cardiac arrest syndrome.Acute and critical care · 2019Review
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Authors and funding
7 authors.
Funding
Abstract
backgroundAcute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) is a well-known predictor for mortality. However, the natural course of AKI including recovery rate after OHCA is uncertain. This study investigated the clinical course of AKI after OHCA and determined whether recovery from AKI impacted the outcomes of OHCA.
methodsThis retrospective multicentre cohort study included adult OHCA patients treated with targeted temperature management (TTM) between January 2016 and December 2017. AKI was diagnosed using the Kidney Disease: Improving Global Outcomes criteria. The primary outcome was the recovery rate after AKI and its association with survival and good neurological outcome at discharge.
resultsA total of 3697 OHCA patients from six hospitals were screened and 275 were finally included. AKI developed in 175/275 (64%) patients and 69/175 (39%) patients recovered from AKI. In most cases, AKI developed within three days of return of spontaneous circulation [155/175 (89%), median time to AKI development 1 (1-2) day] and patients recovered within seven days of return of spontaneous circulation [59/69 (86%), median time to AKI recovery 3 (2-7) days]. Duration of AKI was significantly longer in the AKI non-recovery group than in the AKI recovery group [5 (2-9) vs. 1 (1-5) days; P < 0.001]. Most patients were diagnosed with AKI stage 1 initially [120/175 (69%)]. However, the number of stage 3 AKI patients increased from 30/175 (17%) to 77/175 (44%) after the initial diagnosis of AKI. The rate of survival discharge was significantly higher in the AKI recovery group than in the AKI non-recovery group [45/69 (65%) vs. 17/106 (16%); P < 0.001]. Recovery from AKI was a potent predictor of survival and good neurological outcome at discharge in the multivariate analysis (adjusted odds ratio, 8.308; 95% confidence interval, 3.120-22.123; P < 0.001 and adjusted odds ratio, 36.822; 95% confidence interval, 4.097-330.926; P = 0.001).
conclusionsIn our cohort of adult OHCA patients treated with TTM (n = 275), the recovery rate from AKI after OHCA was 39%, and recovery from AKI was a potent predictor of survival and good neurological outcome at discharge.
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