Evidence map›Paper›PMID 31307399›Full record

ArticleBMC genomics2019

Sex-specific changes in gene expression in response to estrogen pollution around the onset of sex differentiation in grayling (Salmonidae).

Oliver M Selmoni, Diane Maitre, Julien Roux, Laetitia G E Wilkins, Lucas Marques da Cunha, Etienne L M Vermeirssen, Susanne Knörr, Marc Robinson-Rechavi, Claus Wedekind

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Reproductive Potential of Stone Moroko (Animals : an open access journal from MDPI · 2021
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  2. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Oliver M SelmoniDepartment of Ecology and Evolution Biophore, University of Lausanne, Lausanne, Switzerland.
Diane MaitreDepartment of Ecology and Evolution Biophore, University of Lausanne, Lausanne, Switzerland.
Julien RouxDepartment of Ecology and Evolution Biophore, University of Lausanne, Lausanne, Switzerland.
Laetitia G E WilkinsDepartment of Ecology and Evolution Biophore, University of Lausanne, Lausanne, Switzerland.
Lucas Marques da CunhaDepartment of Ecology and Evolution Biophore, University of Lausanne, Lausanne, Switzerland.
Etienne L M VermeirssenSwiss Centre for Applied Ecotoxicology Eawag-EPFL, Dübendorf, Switzerland.
Susanne KnörrAquatic Ecology and Toxicology Group Center of Organismic Studies, University of Heidelberg, Heidelberg, Germany.
Marc Robinson-RechaviDepartment of Ecology and Evolution Biophore, University of Lausanne, Lausanne, Switzerland.
Claus WedekindDepartment of Ecology and Evolution Biophore, University of Lausanne, Lausanne, Switzerland. claus.wedekind@unil.ch.ORCID http://orcid.org/0000-0001-6143-4716
University of Lausanne · CHÉcole Polytechnique Fédérale de Lausanne · CHSIB Swiss Institute of Bioinformatics · CHHeidelberg University · DEUniversity of California, Berkeley · US

Funding

Bundesamt für Umwelt noneSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A_159579Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A_182265
6 · The paper itself

Abstract

The synthetic 17α-ethinylestradiol (EE2) is a common estrogenic pollutant that has been suspected to affect the demography of river-dwelling salmonids. One possibility is that exposure to EE2 tips the balance during initial steps of sex differentiation, so that male genotypes show female-specific gene expression and gonad formation. Here we study EE2 effects on gene expression around the onset of sex differentiation in a population of European grayling (Thymallus thymallus) that suffers from sex ratio distortions. We exposed singly-raised embryos to one dose of 1 ng/L EE2, studied gene expression 10 days before hatching, at the day of hatching, and around the end of the yolk-sac stage, and related it to genetic sex (sdY genotype). We found that exposure to EE2 affects expression of a large number of genes, especially around hatching. These effects were strongly sex-dependent. We then raised fish for several months after hatching and found no evidence of sex reversal in the EE2-exposed fish. We conclude that ecologically relevant (i.e. low) levels of EE2 pollution do not cause sex reversal by simply tipping the balance at early stages of sex differentiation, but that they interfere with sex-specific gene expression.

Indexed as

AnimalsEndocrine DisruptorsEstrogensEthinyl EstradiolFemaleGene ExpressionMaleSalmonidaeSex DifferentiationSex RatioWater Pollutants, ChemicalEndocrine DisruptorsEstrogensEthinyl EstradiolWater Pollutants, Chemical

Identifiers

PMID31307399
PMCPMC6631537
OpenAlexW2958665247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.