Evidence map›Paper›PMID 31307323›Full record

ReviewJournal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses

Symptoms in Children Receiving Treatment for Cancer-Part II: Pain, Sadness, and Symptom Clusters.

Lauri A Linder, Mary C Hooke

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05434871 naunknown statusnot on this map

The Efficacy of Yoga in Pediatric Cancer Patients: A Randomized Controlled Study

TypeinterventionalSponsorAkdeniz UniversityRan2022 to 2023Enrolled40ConditionsCancer, Pediatric CancerArmsYoga training, Physiotherapy
NCT06179914 completednot on this map

Validation of Resilience Models About Cancer in Adolescence and Youth in Taiwan

Typeobservational_patient_registrySponsorKaohsiung Medical University Chung-Ho Memorial HospitalRan2020 to 2022Enrolled223ConditionsChildhood Cancer, Coping Behavior, Hope, Resilience
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Pooled it
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  5. A Randomized Controlled Trial of Animal-assisted Activities for Pediatric Oncology Patients: Psychosocial and Microbial Outcomes.Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners
    Trial
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  7. Scaling up symptom screening for routine use in pediatric oncology: provincial implementation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Designing and Validating Cuidador Web App for Self-Reported Pain among Children and Adolescents in Oncology Care.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026
    Article
  12. Article
  13. Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Lauri A Linder1 University of Utah College of Nursing, Salt Lake City, UT, USA.ORCID 0000-0003-2638-4164
Mary C Hooke3 University of Minnesota School of Nursing, Minneapolis, MN, USA.ORCID 0000-0002-6137-9224
Primary Children's Hospital · USUniversity of Minnesota · US

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
Symptom Assessment during Childhood Cancer TreatmentR13CA232442 · NCI · DUKE UNIVERSITY · PI HOCKENBERRY, MARILYN J · 2018 to 2018
$5k
NCI NIH HHS R13 CA232442NCI NIH HHS U10 CA180886
6 · The paper itself

Abstract

Children and adolescents receiving treatment for cancer experience multiple symptoms as a consequence of their disease and its treatment that interfere with the child's quality of life. Understanding of symptom assessment in children with cancer is foundational to the work of the Children's Oncology Group Nursing Discipline, whose research aims are to address knowledge gaps including understanding illness-related distress. This article is the second of a two-part summary of current evidence addressing the assessment of symptoms frequently reported by children and adolescents receiving treatment for cancer. Studies reporting assessment of pain, sadness, and symptom clusters published between January 2008 and May 2018 were included. Forty-three publications addressed pain. Pain was highly prevalent and distressing, varied in its trajectory across a cycle of chemotherapy and across multiple cycles of treatment, and correlated with biomarkers associated with the pain response. Consequences of pain were poorer functional status and emotional health. Twenty publications addressed sadness. Sadness was the most prevalent psychosocial symptom. Its prevalence decreased over the course of treatment and over a cycle of chemotherapy. Persistent sadness was of greater severity and distress. Eight publications addressed symptom clusters. These studies identified both groups of co-occurring symptoms and groups of patients with common symptom profiles. This two-article series provides evidence for the distressing nature of symptoms among children receiving cancer treatment. Efforts to support clinicians in routine symptom assessment are needed. Additional research directed at alleviating symptoms and building resilience among the child experiencing symptoms is needed.

Indexed as

Drug-Related Side Effects and Adverse ReactionsSyndromeAdolescentAntineoplastic AgentsChildChild, PreschoolFemaleHumansMaleNeoplasmsPainQuality of LifeSadnessAntineoplastic Agentschildhood cancerpainsadnesssymptom clusterssymptoms

Identifiers

PMID31307323
PMCPMC7197222
OpenAlexW2959543553

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.