Evidence map›Paper›PMID 31307321›Full record

ReviewJournal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses

Symptoms in Children Receiving Treatment for Cancer-Part I: Fatigue, Sleep Disturbance, and Nausea/Vomiting.

Mary C Hooke, Lauri A Linder

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05434871 (The Efficacy of Yoga in Pediatric Cancer Patients), which is not on this map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05434871 naunknown statusnot on this map

The Efficacy of Yoga in Pediatric Cancer Patients: A Randomized Controlled Study

TypeinterventionalSponsorAkdeniz UniversityRan2022 to 2023Enrolled40ConditionsCancer, Pediatric CancerArmsYoga training, Physiotherapy
3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Trial
  2. Scaling up symptom screening for routine use in pediatric oncology: provincial implementation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Understanding the influence of social determinants of health on symptom reporting in pediatric cancer.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Usability Evaluation of the RevisedChildren (Basel, Switzerland) · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mary C Hooke1 University of Minnesota School of Nursing, Minneapolis, MN, USA.ORCID 0000-0002-6137-9224
Lauri A Linder3 University of Utah College of Nursing, Salt Lake City, UT, USA.ORCID 0000-0003-2638-4164

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
Symptom Assessment during Childhood Cancer TreatmentR13CA232442 · NCI · DUKE UNIVERSITY · PI HOCKENBERRY, MARILYN J · 2018 to 2018
$5k
NCI NIH HHS R13 CA232442NCI NIH HHS U10 CA180886
6 · The paper itself

Abstract

Children and adolescents with cancer often undergo intensive chemotherapy treatment to obtain remission and long-term survival. The pursuit of successful treatment outcomes may lead to high levels of symptom distress related to treatment side effects and toxicities. The Children's Oncology Group Nursing Discipline held a State of the Science Symposium "Symptom Assessment During Childhood Cancer Treatment" in 2018 that included reviews of evidence regarding key symptoms. The purpose of this review is to summarize and synthesize the evidence presented about the prevalence, relationships, trajectories, and associated biomarkers of selected symptoms experienced by children and adolescents during cancer treatment. Five symptoms were selected, with the focus on fatigue, sleep disturbance, and nausea/vomiting and included in Part I of the review. Using Ovid-Medline, studies published between 2008 and 2018 that focused on these specific symptoms during active chemotherapy treatment were selected. Fatigue interferes with normal developmental activities and is associated with sleep disturbances, and its pattern changes within a cycle of chemotherapy as well as across the treatment trajectory. Sleep is disrupted by the hospital environment, treatment medications, and changes in normal childhood and schedules. Disturbances of sleep persist during treatment, preventing recovery from poor quality sleep. Although pharmacologic interventions have advanced for treatment of nausea and vomiting, children and adolescents continue to struggle with this symptom. Its trajectory changes with the intensity of treatment, and over half of the patients report that they experience nausea and/or vomiting. Future research is needed to advance identification of biologic risk factors for symptoms and test effectiveness of symptom-related interventions.

Indexed as

Drug-Related Side Effects and Adverse ReactionsAdolescentAntineoplastic AgentsChildChild, PreschoolFatigueFemaleHumansMaleNauseaNeoplasmsSleep Wake DisordersVomitingAntineoplastic Agentsfatigueside effects of treatmentsleepsymptoms

Identifiers

PMID31307321
PMCPMC7197223

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.