Evidence map›Paper›PMID 31307305›Full record

ArticleWorld journal for pediatric & congenital heart surgery2019

The Association Between Cardiac Biomarker NT-proBNP and 30-Day Readmission or Mortality After Pediatric Congenital Heart Surgery.

Devin M Parker, Allen D Everett, Meagan E Stabler, JoAnna Leyenaar, Luca Vricella, Jeffrey P Jacobs, Heather Thiessen-Philbrook, Chirag Parikh, Jason H Greenberg, Jeremiah R Brown

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In one paragraph

Article in World journal for pediatric & congenital heart surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Devin M Parker1 The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Lebanon, NH, USA.
Allen D Everett2 Division of Pediatric Cardiology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Meagan E Stabler3 Department of Epidemiology, Geisel School of Medicine, Lebanon, NH, USA.
JoAnna Leyenaar1 The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Lebanon, NH, USA.
Luca Vricella2 Division of Pediatric Cardiology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jeffrey P Jacobs5 Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Heather Thiessen-Philbrook7 Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Chirag Parikh7 Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jason H Greenberg8 Section of Nephrology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
Jeremiah R Brown1 The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Lebanon, NH, USA.
Johns Hopkins Medicine · USDartmouth Institute for Health Policy and Clinical Practice · USDartmouth College · USJohns Hopkins All Children's Hospital · USJohns Hopkins University · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Novel Biomarkers to Predict Readmission in Pediatric and Adult Heart SurgeryR01HL119664 · NHLBI · DARTMOUTH COLLEGE · PI BROWN, JEREMIAH R · 2014 to 2017
$3.2M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL119664
6 · The paper itself

Abstract

backgroundVery little is known about clinical and biomarker predictors of readmissions following pediatric congenital heart surgery. The cardiac biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP) can help predict readmission in adult populations, but the estimated utility in predicting risk of readmission or mortality after pediatric congenital heart surgery has not previously been studied. Our objective was to evaluate the association between pre- and postoperative serum biomarker levels and 30-day readmission or mortality for pediatric patients undergoing congenital heart surgery.

methodsWe measured pre- and postoperative NT-proBNP levels in two prospective cohorts of 522 pediatric patients <18 years of age who underwent at least one congenital heart operation from 2010 to 2014. Blood samples were collected before and after surgery. We evaluated the association between pre- and postoperative NT-proBNP with readmission or mortality within 30 days of discharge, using multivariate logistic regression, adjusting for covariates based on the Society of Thoracic Surgeons (STS) Congenital Heart Surgery Mortality Risk Model.

resultsThe Johns Hopkins Children's Center cohort and the Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI) cohort demonstrate event rates of 12.9% and 9.4%, respectively, for the composite end point. After adjustment for covariates in the STS congenital risk model, we did not find an association between elevated levels of NT-proBNP and increased risk of readmission or mortality following congenital heart surgery for either cohort.

conclusionsIn our two cohorts, preoperative and postoperative values of NT-proBNP were not significantly associated with readmission or mortality following pediatric congenital heart surgery. These findings will inform future studies evaluating multimarker risk assessment models in the pediatric population.

Indexed as

AdolescentBiomarkersCardiac Surgical ProceduresChildChild, PreschoolFemaleFollow-Up StudiesHeart Defects, CongenitalHospital MortalityHumansInfantInfant, NewbornMaleMarylandNatriuretic Peptide, BrainPatient DischargeBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Protein Precursorsbiomarkerspediatric congenital heart diseasepredictionreadmission

Identifiers

PMID31307305
PMCPMC6698385
OpenAlexW2961102153

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.