Evidence map›Paper›PMID 31307287›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020

Validation and noninvasive kinetic modeling of [

Daniele Bertoglio, Jeroen Verhaeghe, Alan Miranda, Istvan Kertesz, Klaudia Cybulska, Špela Korat, Leonie Wyffels, Sigrid Stroobants, Ladislav Mrzljak, Celia Dominguez and 4 more

Open access · hybridAbstract readValidation Study
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. In Vivo PET Imaging of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  4. Preclinical evaluation of [Journal of molecular medicine (Berlin, Germany) · 2025
    Article
  5. Article
  6. Assessing non-invasive quantitative methods for [European journal of nuclear medicine and molecular imaging · 2025
    Article
  7. Article
  8. Article
  9. Preclinical evaluation of the novel [European journal of nuclear medicine and molecular imaging · 2024
    Article
  10. Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  11. Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  12. Article
  13. Article
  14. Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
  15. Isoflurane and ketamine-xylazine modify pharmacokinetics of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  16. Article
  17. Validation, kinetic modeling, and test-retest reproducibility of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  18. SV2A PET Imaging Is a Noninvasive Marker for the Detection of Spinal Damage in Experimental Models of Spinal Cord Injury.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  19. Article
  20. [ACS medicinal chemistry letters · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Daniele BertoglioMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.ORCID 0000-0003-4205-5432
Jeroen VerhaegheMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Alan MirandaMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Istvan KerteszMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Klaudia CybulskaMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Špela KoratMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Leonie WyffelsMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Sigrid StroobantsMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Ladislav MrzljakCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Celia DominguezCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Longbin LiuCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Mette SkinbjergCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Ignacio Munoz-SanjuanCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Steven StaelensMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
University of Antwerp · BECHDI Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synaptic pathology is associated with several brain disorders, thus positron emission tomography (PET) imaging of synaptic vesicle glycoprotein 2A (SV2A) using the radioligand [

Indexed as

AnimalsBrainImage Processing, Computer-AssistedKineticsMaleMembrane GlycoproteinsMiceMice, Inbred C57BLModels, TheoreticalNerve Tissue ProteinsPositron-Emission TomographyPyridinesPyrrolidinonesRadiopharmaceuticalsSynaptic Vesicles1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-oneMembrane GlycoproteinsNerve Tissue ProteinsPyridinesPyrrolidinonesRadiopharmaceuticalsSv2a protein, mouseAnimal modelskinetic modelingpositron emission tomographySV2Asynaptic density

Identifiers

PMID31307287
PMCPMC7232782
OpenAlexW2958717266

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.