ReviewMovement disorders : official journal of the Movement Disorder Society2019
Hallucinations, somatic-functional disorders of PD-DLB as expressions of thalamic dysfunction.
Review in Movement disorders : official journal of the Movement Disorder Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Neuroanatomical and clinical correlates of prodromal dementia with Lewy bodies: a systematic literature review of neuroimaging findings.Journal of neurology · 2024Pooled it
- Abnormal periodic and aperiodic resting-state electroencephalographic markers in Lewy body and Alzheimer's diseases with cognitive decline.GeroScience · 2026Article
- Reduced volume of neuromodulatory brainstem nuclei is associated with early hallucination-related vulnerability in Parkinson's disease.Brain communications · 2026Article
- Compensatory hallucinogenesis across three neuropsychiatric disorders: a Bayesian account.Brain communications · 2026Review
- Combined Dysfunction of the Amygdala and Nucleus Basalis Underlies Visual Hallucinations in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Visual Hallucinations in Serotonergic Psychedelics and Lewy Body Diseases.Schizophrenia bulletin · 2025Review
- Visual hallucinations in Parkinson's disease are associated with deficits in social perception.Journal of Parkinson's disease · 2025Article
- Behavioural and psychological symptoms among out-patients with different cognitive states: cross-sectional study.BJPsych open · 2025Article
- Visual hallucinations in Parkinson's disease: spotlight on central cholinergic dysfunction.Brain : a journal of neurology · 2025Review
- The altered resting-state functional connectivity of thalamic subregions in patients with globus pharyngeus.Brain imaging and behavior · 2025Article
- Quantitative electroencephalography in the diagnosis of dementia with Lewy bodies.Clinical neurophysiology practice · 2025Review
- Time to add two new disorders to neuropsychiatric aspects of Parkinson's disease.Clinical parkinsonism & related disorders · 2025Review
- Dysfunctional default mode and visual networks underlie cognitive deficits in dementia with Lewy bodies: a resting-state fMRI study.Frontiers in aging neuroscience · 2025Article
- Revealing connectivity patterns of deep brain stimulation efficacy in Parkinson's disease.Scientific reports · 2024Article
- Psychiatric Disorders and Cognitive Fluctuations in Parkinson's Disease: Changing Approaches in the First Decades of the 21st Century.Brain sciences · 2024Review
- Cholinergic deficiency in Parkinson's disease patients with visual hallucinations.Brain : a journal of neurology · 2024Article
- Numerosity estimation of virtual humans as a digital-robotic marker for hallucinations in Parkinson's disease.Nature communications · 2024Article
- Parkinson disease psychosis: from phenomenology to neurobiological mechanisms.Nature reviews. Neurology · 2024Review
- Visual Snow Syndrome in Patient with Migraine: Case Report and Literature Review.Journal of clinical medicine · 2024Review
- Functional connectivity in Lewy body disease with visual hallucinations.European journal of neurology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Hallucinations, delusions, and functional neurological manifestations (conversion and somatic symptom disorders) of Parkinson's disease (PD) and dementia with Lewy bodies increase in frequency with disease progression, predict the onset of cognitive decline, and eventually blend with and are concealed by dementia. These symptoms share the absence of reality constraints and can be considered comparable elements of the PD-dementia with Lewy bodies psychosis. We propose that PD-dementia with Lewy bodies psychotic disorders depend on thalamic dysfunction promoting a theta burst mode and subsequent thalamocortical dysrhythmia with focal cortical coherence to theta electroencephalogram rhythms. This theta electroencephalogram activity, also called fast-theta or pre-alpha, has been shown to predict cognitive decline and fluctuations in Parkinson's disease with dementia and dementia with Lewy bodies. These electroencephalogram alterations are now considered a predictive marker for progression to dementia. The resulting thalamocortical dysrhythmia inhibits the frontal attentional network and favors the decoupling of the default mode network. As the default mode network is involved in integration of self-referential information into conscious perception, unconstrained default mode network activity, as revealed by recent imaging studies, leads to random formation of connections that link strong autobiographical correlates to trivial stimuli, thereby producing hallucinations, delusions, and functional neurological disorders. The thalamocortical dysrhythmia default mode network decoupling hypothesis provides the rationale for the design and testing of novel therapeutic pharmacological and nonpharmacological interventions in the context of PD, PD with dementia, and dementia with Lewy bodies. © 2019 International Parkinson and Movement Disorder Society.
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