ArticlePhysics in medicine and biology2019
Non-invasive determination of blood input function to compute rate of myocardial glucose uptake from dynamic FDG PET images of rat heart in vivo: comparative study between the inferior vena cava and the left ventricular blood pool with spill over and partial volume corrections.
Article in Physics in medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
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- Progressive Cardiac Metabolic Defects Accompany Diastolic and Severe Systolic Dysfunction in Spontaneously Hypertensive Rat Hearts.Journal of the American Heart Association · 2023Article
- Imaging Diverse Pathogenic Bacteria In Vivo withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Phagocytosis in the retina promotes local insulin production in the eye.Nature metabolism · 2023Article
- Article
- Dynamic FDG-PET demonstration of functional brain abnormalities.Annals of clinical and translational neurology · 2022Review
- Advances in Preclinical PET.Seminars in nuclear medicine · 2022Review
- Feasibility of Longitudinal Brain PET with Real-Time Arterial Input Function in Rats.Molecular imaging and biology · 2021Article
- HPhysics in medicine and biology · 2021Article
- Model Corrected Blood Input Function to Compute Cerebral FDG Uptake Rates From Dynamic Total-Body PET Images of RatsFrontiers in medicine · 2021Article
- Metformin Improves Cardiac Metabolism and Function, and Prevents Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats.Journal of the American Heart Association · 2020Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The purpose of this work was to compute blood input function from the inferior vena cava (IVC) with partial volume (PV) corrections and compare to that obtained from the left ventricular blood pool (LVBP) with spill-over (SP) and PV corrections. These were then used to compute and validate rates of myocardial 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake (Ki) from dynamic positron emission tomography (PET) images of rat hearts in vivo in comparison to that obtained from invasive arterial blood sampling. Whole body 60 min dynamic FDG PET/CT imaging of n = 8 control Wistar Kyoto (WKY) rats were performed using Albira trimodal PET/CT/SPECT scanner. Image derived blood input function (IDIF) obtained from IVC corrected for PV averaging (IVC-PV) and IDIF from the left ventricular blood pool (LVBP) with SP and PV corrections (LVBP-SP-PV) were computed. Next, computed Ki (indirect comparison) in a 5-parameter (using IVC-PV) and a 15-parameter (using LVBP-SP-PV) 3-compartment models in WKY rat hearts in vivo were compared to that obtained using arterial blood sampling reported in literature in control Spraque Dawley (SD) rats. Using IVC-PV in a three-compartment five-parameter model resulted in a ~46% deviation in the mean computed Ki compared to that obtained with LVBP-SP-PV in a three-compartment 15-parameter model with a ~57% deviation in the mean computed Ki. The mean computed Ki in WKY rat hearts using the above methods, however, did not differ significantly to that obtained from invasive arterial blood sampling in SD rat hearts (p = 0.91 for IVC-PV and p = 0.58 for LVBP-SP-PV). Hence, Ki obtained in WKY rat hearts with input curve from IVC (IVC-PV) in a dynamic FDG PET scan is comparatively more repetitive to that obtained from the LVBP (LVBP-SP-PV). Ki computed using both the methods, however, agree well with each other and that obtained using arterial blood sampling.
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