ArticleAging2019
D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- D-Ribose Glycation of Human High-Density Lipoprotein: Structural and Functional Alterations.International journal of molecular sciences · 2026Article
- Effects of lithium on mortality and metabolite profiles in Drosophila lithium-inducible SLC6 transporter mutants.Environmental toxicology and pharmacology · 2025Article
- Binding of RAGE and RIPK1 induces cognitive deficits in chronic hyperglycemia-derived neuroinflammation.CNS neuroscience & therapeutics · 2024Article
- D-ribose metabolic disorder and diabetes mellitus.Molecular biology reports · 2024Review
- Oral D-ribose causes depressive-like behavior by altering glycerophospholipid metabolism via the gut-brain axis.Communications biology · 2024Article
- Gas Chromatography-Mass Spectrometry-Based Cerebrospinal Fluid Metabolomics to Reveal the Protection of Coptisine against Transient Focal Cerebral Ischemia-Reperfusion Injury via Anti-Inflammation and Antioxidant.Molecules (Basel, Switzerland) · 2023Article
- Berberine Rescues D-Ribose-Induced Alzheimer's Pathology via Promoting Mitophagy.International journal of molecular sciences · 2023Article
- The potential role of albumin glycation by ribose in diabetes mellitus.Science China. Life sciences · 2022Article
- Ribose Intake as Food Integrator: Is It a Really Convenient Practice?Biomolecules · 2022Review
- Urine D-ribose levels correlate with cognitive function in community-dwelling older adults.BMC geriatrics · 2022Article
- Effect of ribose-glycated BSA on histone demethylation.Frontiers in genetics · 2022Article
- B Vitamins Supplementation Can Improve Cognitive Functions and May Relate to the Enhancement of Transketolase Activity in A Rat Model of Cognitive Impairment Associated with High-fat Diets.Current medical science · 2021Article
- D-ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review).Experimental and therapeutic medicine · 2021Review
- Mechanical characterization of native and sugar-modified decellularized kidneys.Journal of the mechanical behavior of biomedical materials · 2021Article
- D-ribose and pathogenesis of Alzheimer's disease.Molecular biology reports · 2020Review
- Connecting Alzheimer's Disease With Diabetes Mellitus Through Amyloidogenic Evolvability.Frontiers in aging neuroscience · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although many mechanisms have been proposed for diabetic encephalopathy in type 2 diabetes mellitus (T2DM), the risk factors for cognitive impairment in type 1 diabetes mellitus (T1DM) are less clear. Here, we show that streptozotocin (STZ)-induced T1DM rats showed cognitive impairment in both Y maze and Morris water maze assays, accompanied with D-ribose was significantly increased in blood and urine, in addition to D-glucose. Furthermore, advanced glycation end products (AGE), Tau hyperphosphorylation and neuronal death in the hippocampal CA4/DG region were detected in T1DM rats. The expression and activity of transketolase (TKT), an important enzyme in the pentose shunt, were decreased in the brain, indicating that TKT may be involved in D-ribose metabolism in T1DM. Support for these change was demonstrated by the activation of TKT with benfotiamine (BTMP) treatment. Decreased D-ribose levels but not D-glucose levels; markedly reduced AGE accumulation, Tau hyperphosphorylation, and neuronal death; and improved cognitive ability in T1DM rats were shown after BTMP administration. In clinical investigation, T1DM patients had high D-ribose levels in both urine and serum. Our work suggests that D-ribose is involved in the cognitive impairment in T1DM and may provide a potentially novel target for treating diabetic encephalopathy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.