ArticleiScience2019
Activation of Cortical Somatostatin Interneurons Rescues Synapse Loss and Motor Deficits after Acute MPTP Infusion.
Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
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- Anesthesia-induced hippocampal-cortical hyperactivity and tau hyperphosphorylation impair remote memory retrieval in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms.International journal of molecular sciences · 2023Article
- The glucocorticoid footprint on the memory engram.Current opinion in endocrine and metabolic research · 2022Article
- Dysregulated cortical synaptic plasticity under methyl-CpG binding protein 2 deficiency and its implication in motor impairments.World journal of psychiatry · 2022Review
- Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Review
- Somatostatin and Somatostatin-Containing Interneurons-From Plasticity to Pathology.Biomolecules · 2022Review
- Long-term changes of parvalbumin- and somatostatin-positive interneurons of the primary motor cortex after chronic social defeat stress depend on individual stress-vulnerability.Frontiers in psychiatry · 2022Article
- Physical exercise rescues cocaine-evoked synaptic deficits in motor cortex.Molecular psychiatry · 2021Article
- Electroacupuncture activates inhibitory neural circuits in the somatosensory cortex to relieve neuropathic pain.iScience · 2021Article
- Neurotransmitters, Cell Types, and Circuit Mechanisms of Motor Skill Learning and Clinical Applications.Frontiers in neurology · 2021Review
- The human motor cortex microcircuit: insights for neurodegenerative disease.Nature reviews. Neuroscience · 2020Review
- Commentary: Activation of Cortical Somatostatin Interneurons Rescues Synapse Loss and Motor Deficits After Acute MPTP Infusion.Frontiers in cellular neuroscience · 2019Article
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult dendritic spines present structural and functional plasticity, which forms the basis of learning and memory. To provide in vivo evidence of spine plasticity under neurotoxicity, we generated an acute motor deficit model by single injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into adult mice. Acute MPTP infusion impairs motor learnings across test paradigms. In vivo two-photon imaging further revealed MPTP-induced prominent dendritic spine loss and substantially increased calcium spikes in apical tufts of layer 5 pyramidal neurons in the motor cortex. MPTP infusion also decreased the activity of somatostatin (SST)-expressing inhibitory interneurons. Further chemogenetic re-activation of SST interneurons reversed MPTP-induced hyperactivation of dendrites, rescued spine loss, and enhanced motor learning. Taken together, our study reports MPTP-induced structural and functional deficits of dendritic spines and suggests the potency of modulating local inhibitory transmission to relieve neurological disorders.
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