ArticleJournal of affective disorders2019
Infancy onset maltreatment and the development of suicide ideation: An investigation of moderation by oxytocin-related gene polymorphisms.
Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Beyond mental disorders: The role of child maltreatment in childhood suicidal behaviour.The Australian and New Zealand journal of psychiatry · 2026Article
- Interpersonal Mechanisms Between Child Maltreatment Timing and Young Adult Internalizing and Externalizing Symptomatology.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- Child maltreatment and youth suicide risk: A developmental conceptual model and implications for suicide prevention.Development and psychopathology · 2023Article
- Negative Perceptions of Peer Relationships as Mechanisms in the Association Between Maltreatment Timing and the Development of Psychopathology.Merrill-Palmer quarterly (Wayne State University. Press) · 2023Article
- Child maltreatment and the development of psychopathology: The role of developmental timing and chronicity.Child abuse & neglect · 2021Article
- Preliminary Evidence That CD38 Moderates the Association of Neuroticism on Amygdala-Subgenual Cingulate Connectivity.Frontiers in neuroscience · 2020Article
- [Impact of parenting styles on suicidal tendencies in adolescents with depression: Mediating role of psychological resilience].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSuicide ideation and behavior remains a significant public policy concern. The interpersonal-psychological theory of suicide posits that thwarted belongingness potentiates risk for suicide. Early disruptions in caregiving have documented effects on lifespan social and interpersonal development, and therefore warrants further investigation in suicide research. This novel study investigates risk for suicide ideation conferred by infant-onset child maltreatment and oxytocin genotypes (OXTR and CD38) and tests interactive effects of genetics and early maltreatment experiences.
methodsParticipants (N = 251) were from a longitudinal follow-up study of emerging adults who participated in a research summer camp program as children (wave 1). Childhood maltreatment was coded from child protective service records and buccal cells were obtained from children and genotyped. At wave 2, self-reported suicide ideation and internalizing symptomatology were obtained.
resultsMaltreatment onset in infancy was significantly related to lifetime suicide ideation. The CD38 gene variation moderated this association such that early onset maltreatment was related to suicide ideation among C-carriers only. The OXTR gene did not relate to lifetime suicide ideation, nor did it moderate early onset maltreatment risk. LIMITATIONS: This study was conducted with a relatively small sample, necessitating the combination of genotypes into binary groups. Replication is necessary.
conclusionsChild maltreatment experienced early in development confers significant risk for lifetime suicide ideation. Furthermore, greater risk for suicide ideation was present for those with specific oxytocin genotypes. These findings further emphasize the importance of preventive interventions aimed at decreasing the incidence of maltreatment and increasing support for high risk families.
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