Evidence map›Paper›PMID 31306748›Full record

ArticleGenomics2020

Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women.

Jason Y Y Wong, Han Zhang, Chao A Hsiung, Kouya Shiraishi, Kai Yu, Keitaro Matsuo, Maria Pik Wong, Yun-Chul Hong, Jiucun Wang, Wei Jie Seow and 177 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  11. Causal Inference with Genetic Data: Past, Present, and Future.Cold Spring Harbor perspectives in medicine · 2022
    Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

187 authors at 20 institutions in 9 countries.

Jason Y Y WongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Electronic address: jason.wong@nih.gov.
Han ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Chao A HsiungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Kouya ShiraishiDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
Kai YuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan; Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Maria Pik WongDepartment of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
Yun-Chul HongDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jiucun WangMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Wei Jie SeowSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Zhaoming WangCancer Genomics Research Laboratory, Leidos Biomedical Research Inc, Gaithersburg, MD, USA; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Minsun SongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Department of Statistics, Sookmyung Women's University, Seoul, Republic of Korea.
Hee Nam KimDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
I-Shou ChangNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Nilanjan ChatterjeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Wei HuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Chen WuDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Tetsuya MitsudomiDivision of Thoracic Surgery, Kinki University School of Medicine, Sayama, Japan.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Jin Hee KimDepartment of Integrative Bioscience & Biotechnology, Sejong University, Seoul, Republic of Korea.
Adeline SeowSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Min-Ho ShinDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Lap Ping ChungDepartment of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
She-Juan AnGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Ping WangDepartment of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Yang YangShanghai Pulmonary Hospital, Shanghai, China.
Hong ZhengDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Yasushi YatabeDepartment of Pathology and Molecular Diagnostics, Aichi Cancer Center Central Hospital, Nagoya, Japan.
Xu-Chao ZhangGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Young Tae KimDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Zhihua YinDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Young-Chul KimLung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasun-eup, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Bryan A BassigDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jiang ChangDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
James Chung Man HoDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong.
Bu-Tian JiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Yataro DaigoDepartment of Medical Oncology and Cancer Center, Shiga University of Medical Science, Otsu, Japan; Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Hidemi ItoDivision of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan; Department of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yukihide MomozawaLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
Kyota AshikawaLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Takayuki HondaDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
H Dean HosgoodDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Hiromi SakamotoDivision of Genetics, National Cancer Center Research Institute, Tokyo, Japan.
Hideo KunitohDepartment of Medical Oncology, Japanese Red Cross Medical Center, Tokyo, Japan.
Koji TsutaDepartment of Pathology and Laboratory Medicine, Kansai Medical University, Osaka, Japan.
Shun-Ichi WatanabeDivision of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
Michiaki KuboLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
Yohei MiyagiMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Kanagawa, Japan.
Haruhiko NakayamaDepartment of Thoracic Surgery, Kanagawa Cancer Center, Kanagawa, Japan.
Shingo MatsumotoDivision of Translational Research, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Chiba, Japan.
Masahiro TsuboiDepartment of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan.
Koichi GotoDepartment of Thoracic Oncology, National Cancer Center Hospital East, Japan.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Lei SongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Xing HuaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Osaka, Japan.
Akiteru GotoDepartment of Cellular and Organ Pathology, Graduate School of Medicine, Akita University, Akita City, Japan.
Yoshihiro MinamiyaDepartment of Thoracic Surgery, Graduate School of Medicine, Akita University, Akita City, Japan.
Kimihiro ShimizuDepartment of Integrative Center of General Surgery, Gunma University Hospital, Gunma, Japan.
Kazumi TanakaDepartment of Integrative Center of General Surgery, Gunma University Hospital, Gunma, Japan.
Fusheng WeiChina National Environmental Monitoring Center, Beijing, China.
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Jian SuGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Yeul Hong KimDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
In-Jae OhLung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasun-eup, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Fengju SongDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Wu-Chou SuDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yu-Min ChenDepartment of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Gee-Chen ChangSchool of Medicine, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Kuan-Yu ChenDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.
Ming-Shyan HuangDepartment of Internal Medicine, E-Da Cancer Hospital, School of Medicine, I-Shou University, Kaohsiung, Taiwan.
Li-Hsin ChienNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Yong-Bing XiangState Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Jae Yong ParkLung Cancer Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Sun-Seog KweonDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun-eup, Republic of Korea.
Chien-Jen ChenGenomic Research Center, Academia Sinica, Taipei, Taiwan.
Kyoung-Mu LeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Department of Environmental Health, Korea National Open University, Seoul, Republic of Korea.
Batel BlechterBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Haixin LiDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Biyun QianDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Daru LuMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Jianjun LiuSaw Swee Hock School of Public Health, National University of Singapore, Singapore; Department of Human Genetics, Genome Institute of Singapore, Singapore; School of Life Sciences, Anhui Medical University, Hefei, China.
Hyo-Sung JeonCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Chin-Fu HsiaoInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Jae Sook SungDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Ying-Huang TsaiDivision of Pulmonary and Critical Care Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
Yoo Jin JungDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Huan GuoDepartment of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Zhibin HuDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Wen-Chang WangThe Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Charles C ChungDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc, Gaithersburg, MD, USA.
Laurie BurdettDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc, Gaithersburg, MD, USA.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc, Gaithersburg, MD, USA.
Amy HutchinsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc, Gaithersburg, MD, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Wei WuDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Herbert PangSchool of BioMedical Sciences, The University of Hong Kong, Hong Kong.
Yuqing LiCancer Prevention Institute of California, Fremont, CA, USA.
Jin Eun ChoiCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Kyong Hwa ParkDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Sook Whan SungDepartment of Thoracic and Cardiovascular Surgery, Seoul St Mary's Hospital, The Catholic University of Korea, Republic of Korea.
Li LiuDepartment of Oncology, Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
C H KangDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Meng ZhuDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Chung-Hsing ChenInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Tsung-Ying YangDivision of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Jun XuSchool of Public Health, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Peng GuanDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
Wen TanDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chih-Liang WangDepartment of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Michael HsinDepartment of Cardiothoracic Surgery, Queen Mary Hospital, The University of Hong Kong, China.
Ko-Yung SitDepartment of Cardiothoracic Surgery, Queen Mary Hospital, The University of Hong Kong, China.
James HoDepartment of Medicine, The University of Hong Kong, China.
Ying ChenSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Yi Young ChoiCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Jen-Yu HungDepartment of Internal Medicine, E-Da Cancer Hospital, School of Medicine, I-Shou University, Kaohsiung, Taiwan.
Jun Suk KimDivision of Medical Oncology, Department of Internal Medicine, College of Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.
Ho Il YoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Chien-Chung LinDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
In Kyu ParkDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Ping XuDepartment of Oncology, Wuhan Iron and Steel Corporation Staff Worker Hospital, Wuhan, China.
Yuzhuo WangDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Qincheng HeDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Reury-Perng PerngChest Department, Taipei Veterans General Hospital, Taipei, Taiwan.
Chih-Yi ChenInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Thoracic Surgery, Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan.
Roel VermeulenDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the Netherlands.
Junjie WuMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Wei-Yen LimAgency for Integrated Care, Singapore.
Kun-Chieh ChenDivision of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Yao-Jen LiGenomic Research Center, Academia Sinica, Taipei, Taiwan.
Jihua LiQujing Center for Diseases Control and Prevention, Sanjiangdadao, Qujing, China.
Hongyan ChenMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Chong-Jen YuDepartment of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Li JinMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Tzu-Yu ChenInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Shih-Sheng JiangNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Jie LiuDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Taiki YamajiEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Belynda HicksDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc, Gaithersburg, MD, USA.
Kathleen WyattDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc, Gaithersburg, MD, USA.
Shengchao A LiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc, Gaithersburg, MD, USA.
Juncheng DaiDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Hongxia MaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Guangfu JinDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Bao SongDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Zhehai WangDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Sensen ChengDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Xuelian LiDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
Yangwu RenDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
Ping CuiDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Motoki IwasakiEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Taichi ShimazuEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Shoichiro TsuganeEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Junjie ZhuShanghai Pulmonary Hospital, Shanghai, China.
Ying ChenDepartment of Thoracic Surgery, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, Kunming, China.
Kaiyun YangDepartment of Thoracic Surgery, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, Kunming, China.
Gening JiangShanghai Pulmonary Hospital, Shanghai, China.
Ke FeiShanghai Pulmonary Hospital, Shanghai, China.
Guoping WuChina National Environmental Monitoring Center, Beijing, China.
Hsien-Chin LinInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Hui-Ling ChenInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Yao-Huei FangInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Fang-Yu TsaiNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Wan-Shan HsiehInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Jinming YuDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Victoria L StevensBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
Ite A Laird-OffringaDepartment of Surgery, Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Crystal N MarconettDepartment of Surgery, Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Linda RieswijkEnvironmental Health Sciences Division, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Ann ChaoCenter for Global Health, National Cancer Institute, Bethesda, MD, USA.
Pan-Chyr YangDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Tangchun WuDepartment of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Y L WuGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Dongxin LinDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Kexin ChenDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Baosen ZhouDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Yun-Chao HuangDepartment of Thoracic Surgery, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, Kunming, China.
Takashi KohnoDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
Hongbing ShenDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Seoul National University · KRNational Health Research Institutes · TWChinese Academy of Medical Sciences & Peking Union Medical College · CNLeidos (United States) · USNational Cancer Institute · USTianjin Medical University Cancer Institute and Hospital · CNGuangdong General Hospital · CNShiga University of Medical Science · JPSookmyung Women's University · KRAichi Cancer Center · JPChina Medical University · CNChonnam National University · KRJohns Hopkins University · USNational University of Singapore · SGSejong University · KRAcademy of Medical Sciences · GBCancer Prevention Institute of California · USCenter for Global Health · USFudan University · CNKunming Medical University · CN

Funding

Transdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9M
PROSTATE, LUNG, COLORECTAL, &OVARIAN CANCER SCREENINGN01CN025476 · CN · WESTAT, INC. · PI O'BRIEN, BARBARA B · 1992 to 2000
$7.9M
Shanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9M
Cancer Risk Reduction and Diet: A Cohort Study of WomenR37CA070867 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2009 to 2013
$4.7M
Overcoming acquired resistance to EGFR inhibitors in lung cancerR01CA121210 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LOVLY, CHRISTINE M. · 2007 to 2016
$2.9M
PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCERN01CN025512 · CN · HENRY FORD HEALTH SYSTEM · PI DEMERS, RAYMOND Y · 1992 to 2001
$2.0M
PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCERN01CN075022 · CN · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N. · 1997 to 2001
$1.6M
PROSTATE, LUNG, COLORECTAL &OVARIAN (PLCO) CANCERN01CN025516 · CN · WASHINGTON UNIVERSITY · PI ANDRIOLE, GERALD LOUIS · 1992 to 2001
$1.5M
PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCERN01CN025514 · CN · UNIVERSITY OF COLORADO DENVER · PI CRAWFORD, E DAVID · 1992 to 2000
$1.3M
PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCERN01CN025515 · CN · PACIFIC HEALTH RESEARCH INSTITUTE · PI YOKOCHI, LANCE L · 1992 to 2000
$1.2M
PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCERN01CN025511 · CN · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WEISSFELD, JOEL L · 1992 to 2000
$1.2M
PROSTATE, LUNG, COLORECTAL &OVARIAN CANCERN01CN025522 · CN · GEORGETOWN UNIVERSITY · PI GELMANN, EDWARD P · 1992 to 2000
$817k
CCR NIH HHS N01 RC037004Intramural NIH HHS Z99 CA999999NCI NIH HHS N01 CN025404NCI NIH HHS N01 CN025476NCI NIH HHS N01 CN025511NCI NIH HHS N01 CN025512NCI NIH HHS N01 CN025513NCI NIH HHS N01 CN025514NCI NIH HHS N01 CN025515NCI NIH HHS N01 CN025516NCI NIH HHS N01 CN025518NCI NIH HHS N01 CN025522NCI NIH HHS N01 CN045165NCI NIH HHS N01 CN075022NCI NIH HHS R01 CA121210NCI NIH HHS R37 CA070867NCI NIH HHS U19 CA148127NCI NIH HHS UM1 CA182910
6 · The paper itself

Abstract

We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

Indexed as

Adenocarcinoma of LungAsian PeopleFemaleGenome-Wide Association StudyHumansLung NeoplasmsMendelian Randomization AnalysisNon-SmokersTuberculosis, PulmonaryLung adenocarcinomaLung cancerMendelian randomizationPathway analysisTuberculosis

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PMID31306748
PMCPMC6954985
OpenAlexW3001411588

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.